N-[2-(4-methylphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole]aza-18-crown-6

Base Information

Chemical Name:N-[2-(4-methylphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole]aza-18-crown-6
CAS No.:1267554-15-3
Molecular Formula:C₃₁H₄₃N₃O₆
Molecular Weight:553.699
Hs Code.:

Synonyms:N-[2-(4-methylphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole]aza-18-crown-6

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(4-methylphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole]aza-18-crown-6

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Technology Process of N-[2-(4-methylphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole]aza-18-crown-6

There total 7 articles about N-[2-(4-methylphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole]aza-18-crown-6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 33941-15-0
1-aza-18-crown-6

: 253878-40-9
2-[4-(bromomethyl)phenyl]-5-(4-tert-butylphenyl)-1,3,4-oxadiazole

: 1267554-15-3
N-[2-(4-methylphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole]aza-18-crown-6

Guidance literature:: With potassium carbonate; In acetonitrile; for 5h; Inert atmosphere; Reflux;
DOI:10.1016/j.saa.2010.10.027

Reference yield:

: 94-08-6
4-methylbenzoic acid ethyl ester

: 1267554-15-3
N-[2-(4-methylphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole]aza-18-crown-6

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / 15 h / 80 °C

2: pyridine / 0 °C / Reflux

3: trichlorophosphate / 10 h / 80 °C

4: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux

5: potassium carbonate / acetonitrile / 5 h / Inert atmosphere; Reflux

With pyridine; N-Bromosuccinimide; potassium carbonate; hydrazine hydrate; trichlorophosphate; dibenzoyl peroxide; In tetrachloromethane; acetonitrile;
DOI:10.1016/j.saa.2010.10.027

Reference yield:

: 99-94-5
p-Toluic acid

: 1267554-15-3
N-[2-(4-methylphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole]aza-18-crown-6

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 20 h / Reflux

2: hydrazine hydrate / 15 h / 80 °C

3: pyridine / 0 °C / Reflux

4: trichlorophosphate / 10 h / 80 °C

5: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux

6: potassium carbonate / acetonitrile / 5 h / Inert atmosphere; Reflux

With pyridine; N-Bromosuccinimide; sulfuric acid; potassium carbonate; hydrazine hydrate; trichlorophosphate; dibenzoyl peroxide; In tetrachloromethane; acetonitrile;
DOI:10.1016/j.saa.2010.10.027