C₂₉H₃₉NO₆Si

Base Information

• Chemical Name: C₂₉H₃₉NO₆Si
• CAS No.: 1053613-91-4
• Molecular Formula: C₂₉H₃₉NO₆Si
• Molecular Weight: 525.717
• Mol file: 1053613-91-4.mol

Synonyms:C₂₉H₃₉NO₆Si

Chemical Property of C₂₉H₃₉NO₆Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₃₉NO₆Si

There total 6 articles about C₂₉H₃₉NO₆Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,5S,7R)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-6,8-dioxa-bicyclo[3.2.1]oct-3-en-2-one (221015-46-9) → C29H39NO6Si (1053613-91-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / H₂ / Pd-C / ethyl acetate

2: 70 percent / LHMDS; HMPA / tetrahydrofuran

3: 70 percent / pyridine; H₂O / 2.5 h / Heating

4: LiAlH₄ / tetrahydrofuran / 0 °C

5: aq. K₂CO₃

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; hydrogen; potassium carbonate; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; pyridine; water; ethyl acetate; 1: Hydrogenation / 2: Methylation / 3: <3,3>-sigmatropic rearrangement; cyclization / 4: Reduction / 5: Condensation;

DOI:10.1021/ol006065o

Reference yield:

4-methoxyphenylhydrazine hydrochloride (19501-58-7) → C29H39NO6Si (1053613-91-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / pyridine; H₂O / 2.5 h / Heating

2: LiAlH₄ / tetrahydrofuran / 0 °C

3: aq. K₂CO₃

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; pyridine; water; 1: <3,3>-sigmatropic rearrangement; cyclization / 2: Reduction / 3: Condensation;

DOI:10.1021/ol006065o

Reference yield:

(1S,5S,7R)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-6,8-dioxa-bicyclo[3.2.1]octan-2-one (300676-83-9) → C29H39NO6Si (1053613-91-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / LHMDS; HMPA / tetrahydrofuran

2: 70 percent / pyridine; H₂O / 2.5 h / Heating

3: LiAlH₄ / tetrahydrofuran / 0 °C

4: aq. K₂CO₃

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; pyridine; water; 1: Methylation / 2: <3,3>-sigmatropic rearrangement; cyclization / 3: Reduction / 4: Condensation;

DOI:10.1021/ol006065o

upstream raw materials:

benzyl chloroformate

4-methoxyphenylhydrazine hydrochloride

(1S,5S,7R)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-6,8-dioxa-bicyclo[3.2.1]oct-3-en-2-one

(1S,5S,7R)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-6,8-dioxa-bicyclo[3.2.1]octan-2-one

Downstream raw materials:

(2R,3S)-3-[2-(tert-Butoxycarbonyl-methyl-amino)-ethyl]-2-((S)-1-hydroxy-allyl)-5-methoxy-3-methyl-2,3-dihydro-indole-1-carboxylic acid benzyl ester

2-acetoxy-3-[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-5-methoxy-3-methyl-2,3-dihydro-indole-1-carboxylic acid benzyl ester

(2R,3S)-2-((S)-1-Hydroxy-allyl)-5-methoxy-3-methyl-3-(2-methylamino-ethyl)-2,3-dihydro-indole-1-carboxylic acid benzyl ester

(2R,3S)-2-((S)-1-Hydroxy-allyl)-3-(2-hydroxy-ethyl)-5-methoxy-3-methyl-2,3-dihydro-indole-1-carboxylic acid benzyl ester