(R)-(-)-2-(4-toluenesulfonyloxy)-phenylacetic acid methyl ester

Base Information

• Chemical Name: (R)-(-)-2-(4-toluenesulfonyloxy)-phenylacetic acid methyl ester
• CAS No.: 131981-95-8
• Molecular Formula: C₁₆H₁₆O₅S
• Molecular Weight: 320.366
• Mol file: 131981-95-8.mol

Synonyms:(R)-(-)-2-(4-toluenesulfonyloxy)-phenylacetic acid methyl ester

Chemical Property of (R)-(-)-2-(4-toluenesulfonyloxy)-phenylacetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-2-(4-toluenesulfonyloxy)-phenylacetic acid methyl ester

There total 1 articles about (R)-(-)-2-(4-toluenesulfonyloxy)-phenylacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(R)-methyl mandelate (20698-91-3) + p-toluenesulfonyl chloride (98-59-9) → (R)-(-)-2-(4-toluenesulfonyloxy)-phenylacetic acid methyl ester (131981-95-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

Reference yield: 97.0%

(R)-(-)-2-(4-toluenesulfonyloxy)-phenylacetic acid methyl ester (131981-95-8) → (S)-Acetylsulfanyl-phenyl-acetic acid methyl ester (131981-96-9)

Guidance literature:

With Amberlyst; thioacetate form;

DOI:10.1016/S0040-4039(00)97877-8

Reference yield: 90.0%

(R)-(-)-2-(4-toluenesulfonyloxy)-phenylacetic acid methyl ester (131981-95-8) + (2S)-2-piperidinecarboxamide (19889-77-1,24735-67-9,65057-28-5,78088-51-4) → (2S,αS)-α-(2-carbamoylpiperidinyl)-α-phenylacetic acid methyl ester (1191446-35-1)

Guidance literature:

With pyridine; In acetonitrile; for 1h; optical yield given as %de; diastereoselective reaction; Reflux;

DOI:10.1016/j.tetasy.2009.06.022

upstream raw materials:

(R)-methyl mandelate

p-toluenesulfonyl chloride

Downstream raw materials:

(S)-Acetylsulfanyl-phenyl-acetic acid methyl ester

(2S,αS)-α-(2-carbamoylpyrrolidin-1-yl)-α-phenylacetic acid methyl ester

(2S,αR)-α-(2-carbamoylpyrrolidin-1-yl)-α-phenylacetic acid methyl ester

(S)-2-mercapto-2-phenylethanol