(5-chloro-2-nitro-phenyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol

Base Information

Chemical Name:(5-chloro-2-nitro-phenyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol
CAS No.:1441141-81-6
Molecular Formula:C₁₇H₁₀Cl₂F₃N₃O₃
Molecular Weight:432.186
Hs Code.:

Synonyms:(5-chloro-2-nitro-phenyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol

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Chemical Property of (5-chloro-2-nitro-phenyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol

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Technology Process of (5-chloro-2-nitro-phenyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol

There total 3 articles about (5-chloro-2-nitro-phenyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6628-86-0
5-chloro-2-nitrobenzaldehyde

: 1441141-71-4
1-[4-chloro-3-(trifluoromethyl)phenyl]-4-iodopyrazole

: 1441141-81-6
(5-chloro-2-nitro-phenyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol

Guidance literature:: 1-[4-chloro-3-(trifluoromethyl)phenyl]-4-iodopyrazole; With isopropylmagnesium chloride; In tetrahydrofuran; at -20 - 0 ℃; for 1h;

5-chloro-2-nitrobenzaldehyde; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 445-01-2
5-bromo-2-chlorobenzotrifluoride

: 1441141-81-6
(5-chloro-2-nitro-phenyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; sodium carbonate; sodium L-ascorbate / dimethyl sulfoxide / 52 h / 100 - 140 °C / Inert atmosphere

2.1: N-iodo-succinimide; acetic acid / 0.25 h / 150 °C / Microwave irradiation

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 - 0 °C

3.2: 2 h / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; N-iodo-succinimide; copper(l) iodide; isopropylmagnesium chloride; sodium carbonate; acetic acid; sodium L-ascorbate; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 1441141-76-9
1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole

: 1441141-81-6
(5-chloro-2-nitro-phenyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-iodo-succinimide; acetic acid / 0.25 h / 150 °C / Microwave irradiation

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 - 0 °C

2.2: 2 h / 20 °C

With N-iodo-succinimide; isopropylmagnesium chloride; acetic acid; In tetrahydrofuran;