benzyl 4-[5-(aminocarbonyl)-4,5-dihydroisoxazol-3-yl]piperazine-1-carboxylate

Base Information

Chemical Name:benzyl 4-[5-(aminocarbonyl)-4,5-dihydroisoxazol-3-yl]piperazine-1-carboxylate
CAS No.:1241898-19-0
Molecular Formula:C₁₆H₂₀N₄O₄
Molecular Weight:332.359
Hs Code.:

Synonyms:benzyl 4-[5-(aminocarbonyl)-4,5-dihydroisoxazol-3-yl]piperazine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl 4-[5-(aminocarbonyl)-4,5-dihydroisoxazol-3-yl]piperazine-1-carboxylate

Chemical Property:

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Technology Process of benzyl 4-[5-(aminocarbonyl)-4,5-dihydroisoxazol-3-yl]piperazine-1-carboxylate

There total 1 articles about benzyl 4-[5-(aminocarbonyl)-4,5-dihydroisoxazol-3-yl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31166-44-6
phenylmethyl 1-piperazinecarboxylate

: 1030613-69-4
3-bromo-4,5-dihydro-isoxazole-5-carboxylic acid amide

: 1241898-19-0
benzyl 4-[5-(aminocarbonyl)-4,5-dihydroisoxazol-3-yl]piperazine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 100 ℃; for 18h;

Reference yield:

: 1241898-19-0
benzyl 4-[5-(aminocarbonyl)-4,5-dihydroisoxazol-3-yl]piperazine-1-carboxylate

: 1241898-20-3
benzyl 4-[5-(aminocarbonyl)isoxazol-3-yl]piperazine-1-carboxylate

Guidance literature:: With iodine; sodium acetate; In toluene; for 12h; Reflux;

Reference yield:

: 1241898-19-0
benzyl 4-[5-(aminocarbonyl)-4,5-dihydroisoxazol-3-yl]piperazine-1-carboxylate

: 1241896-46-7
{5-[3-(4-{[3-(trifluoromethoxy)phenyl]carbonyl}piperazin-1-yl)isoxazol-5-yl]-2H-tetrazol-2-yl}acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: sodium acetate; iodine / toluene / 12 h / Reflux

2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

3: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 1 h / 100 °C

4: triethylamine / tetrahydrofuran / 1 h / 80 °C

5: hydrogen / palladium on activated charcoal / ethanol; tetrahydrofuran / 3 h / 20 °C

6: triethylamine / acetonitrile; water; tetrahydrofuran / 15 h / 20 °C

7: sodium hydroxide; water / water; tetrahydrofuran; methanol / 0.25 h

With sodium azide; water; hydrogen; iodine; sodium acetate; ammonium chloride; triethylamine; trifluoroacetic anhydride; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;