tert-butyl 4-[5-fluoro-4-(2-fluoro-4-mesylphenoxy)pyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[5-fluoro-4-(2-fluoro-4-mesylphenoxy)pyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate
CAS No.:1236281-74-5
Molecular Formula:C₂₃H₂₆F₂N₄O₅S
Molecular Weight:508.546
Hs Code.:

Synonyms:tert-butyl 4-[5-fluoro-4-(2-fluoro-4-mesylphenoxy)pyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[5-fluoro-4-(2-fluoro-4-mesylphenoxy)pyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[5-fluoro-4-(2-fluoro-4-mesylphenoxy)pyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-[5-fluoro-4-(2-fluoro-4-mesylphenoxy)pyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 398456-87-6
2-fluoro-4-(methanesulfonyl)phenol

: 1236284-39-1
tert-butyl 4-(4-chloro-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl)piperidine-1-carboxylate

: 1236281-74-5
tert-butyl 4-[5-fluoro-4-(2-fluoro-4-mesylphenoxy)pyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 100 ℃; for 1h;

Reference yield:

: 2105-94-4
4-bromo-2-fluorophenol

: 1236281-74-5
tert-butyl 4-[5-fluoro-4-(2-fluoro-4-mesylphenoxy)pyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N`-dimethylethylenediamine / copper(I) trifluoromethanesulfonate benzene / dimethyl sulfoxide / 21 h / 140 °C / Inert atmosphere

2: potassium carbonate / dimethyl sulfoxide / 1 h / 100 °C

With potassium carbonate; N,N`-dimethylethylenediamine; copper(I) trifluoromethanesulfonate benzene; In dimethyl sulfoxide;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1236281-74-5
tert-butyl 4-[5-fluoro-4-(2-fluoro-4-mesylphenoxy)pyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Selectfluor; acetic acid / acetonitrile / 18 h / 70 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3: potassium carbonate / dimethyl sulfoxide / 1 h / 100 °C

With potassium carbonate; acetic acid; Selectfluor; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dimethyl sulfoxide; toluene; acetonitrile;