6-(3,4-dimethoxyphenyl)-4-(1-methyl-1H-pyrrol-2-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

Base Information

• Chemical Name: 6-(3,4-dimethoxyphenyl)-4-(1-methyl-1H-pyrrol-2-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
• CAS No.: 869494-92-8
• Molecular Formula: C₁₉H₁₇N₃O₃
• Molecular Weight: 335.362
• Mol file: 869494-92-8.mol

Synonyms:6-(3,4-dimethoxyphenyl)-4-(1-methyl-1H-pyrrol-2-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

Chemical Property of 6-(3,4-dimethoxyphenyl)-4-(1-methyl-1H-pyrrol-2-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(3,4-dimethoxyphenyl)-4-(1-methyl-1H-pyrrol-2-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

There total 4 articles about 6-(3,4-dimethoxyphenyl)-4-(1-methyl-1H-pyrrol-2-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-methylpyrrole aldehyde (1192-58-1) + ethyl 2-cyanoacetate (105-56-6) + 1-(3,4-dimethoxyphenyl)ethanone (1131-62-0) → 6-(3,4-dimethoxyphenyl)-4-(1-methyl-1H-pyrrol-2-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (869494-92-8)

Guidance literature:

With ammonium acetate; In neat (no solvent); at 100 ℃; for 0.166667h; Microwave irradiation; Sealed tube;

DOI:10.1016/j.ejmech.2015.01.023

Reference yield:

N-methylpyrrole aldehyde (1192-58-1) → 6-(3,4-dimethoxyphenyl)-4-(1-methyl-1H-pyrrol-2-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (869494-92-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 20 °C

2: ammonium acetate / ethanol / Reflux

With ammonium acetate; potassium hydroxide; In ethanol; 1: Claisen Schmidt condensation;

DOI:10.1007/s00044-010-9469-0

Reference yield:

1-(3,4-dimethoxyphenyl)ethanone (1131-62-0) → 6-(3,4-dimethoxyphenyl)-4-(1-methyl-1H-pyrrol-2-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (869494-92-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 20 °C

2: ammonium acetate / ethanol / Reflux

With ammonium acetate; potassium hydroxide; In ethanol; 1: Claisen Schmidt condensation;

DOI:10.1007/s00044-010-9469-0

upstream raw materials:

N-methylpyrrole aldehyde

ethyl 2-cyanoacetate

1-(3,4-dimethoxyphenyl)ethanone

C₁₆H₁₇NO₃

Downstream raw materials:

C₂₀H₁₇N₃O₄

C₂₁H₁₉N₅O₂

C₂₁H₁₉N₃O₄

C₂₆H₂₃N₃O₃