3-(biphenyl-4-yl)-2-(4-fluorophenyl)-6-(morpholin-1-yl)imidazo[1,2-a]pyridine

Base Information

Chemical Name:3-(biphenyl-4-yl)-2-(4-fluorophenyl)-6-(morpholin-1-yl)imidazo[1,2-a]pyridine
CAS No.:1443985-71-4
Molecular Formula:C₂₉H₂₄FN₃O
Molecular Weight:449.527
Hs Code.:

Synonyms:3-(biphenyl-4-yl)-2-(4-fluorophenyl)-6-(morpholin-1-yl)imidazo[1,2-a]pyridine

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Chemical Property of 3-(biphenyl-4-yl)-2-(4-fluorophenyl)-6-(morpholin-1-yl)imidazo[1,2-a]pyridine

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Technology Process of 3-(biphenyl-4-yl)-2-(4-fluorophenyl)-6-(morpholin-1-yl)imidazo[1,2-a]pyridine

There total 3 articles about 3-(biphenyl-4-yl)-2-(4-fluorophenyl)-6-(morpholin-1-yl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1443986-19-3
2-(4-fluorophenyl)-3-iodo-6-(morpholin-1-yl)imidazo[1,2-a]pyridine

: 5122-94-1
4-biphenylboronic acid

: 1443985-71-4
3-(biphenyl-4-yl)-2-(4-fluorophenyl)-6-(morpholin-1-yl)imidazo[1,2-a]pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.03.054

Reference yield:

: 6-(N-morpholino)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine

: 1443985-71-4
3-(biphenyl-4-yl)-2-(4-fluorophenyl)-6-(morpholin-1-yl)imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: N-iodo-succinimide / acetonitrile / 3 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 4 h / 100 °C / Inert atmosphere

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.03.054

Reference yield:

: 478040-44-7
6-iodo-2-(4-fluorophenyl)imidazo[1,2-a]pyridine

: 1443985-71-4
3-(biphenyl-4-yl)-2-(4-fluorophenyl)-6-(morpholin-1-yl)imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; potassium phosphate / isopropyl alcohol; ethylene glycol / Reflux

2: N-iodo-succinimide / acetonitrile / 3 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 4 h / 100 °C / Inert atmosphere

With potassium phosphate; N-iodo-succinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; ethylene glycol; isopropyl alcohol; acetonitrile; 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.03.054