5-(2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole

Base Information

Chemical Name:5-(2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole
CAS No.:1330277-14-9
Molecular Formula:C₃₃H₂₅BrN₄
Molecular Weight:561.461
Hs Code.:

5-(2',3',5',6'-tetra-[<sup>2</sup>H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole

Synonyms:5-(2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole

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Chemical Property of 5-(2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole

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Technology Process of 5-(2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole

There total 7 articles about 5-(2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.9%

: 1420880-38-1
5-(2',3',5',6'-tetra-[²H]-4'-methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

: 1330277-14-9
5-(2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole

Guidance literature:: With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 3h; Reflux;
DOI:10.1002/jlcr.2956

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 1330277-14-9
5-(2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium; iodine / tetrahydrofuran / 2.5 h / 20 - 50 °C

1.2: 8 h / 20 °C

2.1: trichlorophosphate; pyridine / 3 h / 105 °C / Cooling with ice

3.1: toluene / 16 h / Reflux

4.1: triethylamine / dichloromethane / 2.75 h / 20 °C / Cooling with ice

5.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

With pyridine; N-Bromosuccinimide; iodine; magnesium; triethylamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; toluene; 1.1: |Grignard Reaction;
DOI:10.1002/jlcr.2956

Reference yield:

: 1420880-35-8
4, 4-dimethyl-2-(2',3',5',6'-tetra-[²H]-4'-methyl-biphenyl-2-yl)oxazoline

: 1330277-14-9
5-(2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate; pyridine / 3 h / 105 °C / Cooling with ice

2: toluene / 16 h / Reflux

3: triethylamine / dichloromethane / 2.75 h / 20 °C / Cooling with ice

4: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

With pyridine; N-Bromosuccinimide; triethylamine; trichlorophosphate; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; toluene;
DOI:10.1002/jlcr.2956