N-(2-formyl-1,7-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Base Information

Chemical Name:N-(2-formyl-1,7-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide
CAS No.:1314128-71-6
Molecular Formula:C₂₃H₂₄N₂O₄
Molecular Weight:392.455
Hs Code.:

Synonyms:N-(2-formyl-1,7-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Chemical Property of N-(2-formyl-1,7-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Technology Process of N-(2-formyl-1,7-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

There total 11 articles about N-(2-formyl-1,7-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314128-73-8
C₂₅H₂₈N₂O₅

: 1314128-71-6
N-(2-formyl-1,7-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: C₂₅H₂₈N₂O₅; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;

With manganese(IV) oxide; In tetrahydrofuran; for 20h; Reflux;

Reference yield:

: 603-83-8
3-nitro-o-tolylamine

: 1314128-71-6
N-(2-formyl-1,7-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 0.5 h / -10 - -5 °C

1.2: 0.17 h / -6 - 2 °C

1.3: 1 h / 0 °C

2.1: methanesulfonic acid; Eaton′s Reagent / toluene / 0.33 h / 80 °C

3.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 1.5 h / 0 - 20 °C

4.1: hydrogen / palladium-on-charcoal / ethyl acetate / 18 h / 20 °C / 760.05 Torr

5.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 4 h / 40 °C

5.2: 17 h / 0 - 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 - 20 °C

6.2: 20 h / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; methanesulfonic acid; Eaton′s Reagent; hydrogen; sodium hydride; sodium nitrite; palladium-on-charcoal; In tetrahydrofuran; Pionier 2076; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1314128-63-6
ethyl 1,7-dimethyl-6-nitro-1H-indole-2-carboxylate

: 1314128-71-6
N-(2-formyl-1,7-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium-on-charcoal / ethyl acetate / 18 h / 20 °C / 760.05 Torr

2.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 4 h / 40 °C

2.2: 17 h / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 - 20 °C

3.2: 20 h / Reflux

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; palladium-on-charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene;