methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

Base Information

Chemical Name:methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate
CAS No.:1260170-91-9
Molecular Formula:C₂₆H₃₂N₄O₇S₂
Molecular Weight:576.695
Hs Code.:

Synonyms:methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

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Chemical Property of methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

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Technology Process of methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

There total 8 articles about methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1260170-90-8
methyl (S)-3-(4-hydroxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoate

: 288399-19-9
4-(chloromethyl)-2-methylquinoline

: 1260170-91-9
methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

Guidance literature:: With caesium carbonate; potassium iodide; In acetone; at 20 ℃; for 18h;

Reference yield:

: 54533-09-4
N,N-bis(2-chloroethyl)methanesulfonamide

: 1260170-91-9
methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / 18 h / 127 °C

2: hydrogenchloride / isopropyl alcohol; methanol / 18 h / 40 °C

3: triethylamine / dichloromethane / 3 h / 20 °C

4: hydrogen; acetic acid / palladium 10% on activated carbon / 1,4-dioxane / 18 h / 20 °C

5: potassium iodide; caesium carbonate / acetone / 18 h / 20 °C

With hydrogenchloride; hydrogen; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; isopropyl alcohol; acetone;

Reference yield:

: methyl (S)-3-amino-2-(4-methanesulfonylpiperazin-1-yl)propanoate dihydrochloride

: 1260170-91-9
methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: hydrogen; acetic acid / palladium 10% on activated carbon / 1,4-dioxane / 18 h / 20 °C

3: potassium iodide; caesium carbonate / acetone / 18 h / 20 °C

With hydrogen; caesium carbonate; acetic acid; triethylamine; potassium iodide; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; acetone;