Methyl (9S,12S,15S)-15-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-12-<(4-hydroxyphenyl)methyl>-11,14-dioxo-2-oxa-10,13-diazatricyclo<15.2.2.1^3,7>docosa-3,5,7(22),17,19,20-hexaene-9-carboxylate

Base Information

• Chemical Name: Methyl (9S,12S,15S)-15-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-12-<(4-hydroxyphenyl)methyl>-11,14-dioxo-2-oxa-10,13-diazatricyclo<15.2.2.1^3,7>docosa-3,5,7(22),17,19,20-hexaene-9-carboxylate
• CAS No.: 120363-26-0
• Molecular Formula: C₃₃H₃₇N₃O₉
• Molecular Weight: 619.671

Synonyms:Methyl (9S,12S,15S)-15-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-12-<(4-hydroxyphenyl)methyl>-11,14-dioxo-2-oxa-10,13-diazatricyclo<15.2.2.1^3,7>docosa-3,5,7(22),17,19,20-hexaene-9-carboxylate

Chemical Property of Methyl (9S,12S,15S)-15-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-12-<(4-hydroxyphenyl)methyl>-11,14-dioxo-2-oxa-10,13-diazatricyclo<15.2.2.1^3,7>docosa-3,5,7(22),17,19,20-hexaene-9-carboxylate

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of Methyl (9S,12S,15S)-15-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-12-<(4-hydroxyphenyl)methyl>-11,14-dioxo-2-oxa-10,13-diazatricyclo<15.2.2.1^3,7>docosa-3,5,7(22),17,19,20-hexaene-9-carboxylate

There total 25 articles about Methyl (9S,12S,15S)-15-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-12-<(4-hydroxyphenyl)methyl>-11,14-dioxo-2-oxa-10,13-diazatricyclo<15.2.2.1^3,7>docosa-3,5,7(22),17,19,20-hexaene-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-2-Acetylamino-3-[4-(5-{(S)-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-2-methoxycarbonyl-ethyl}-2-hydroxy-phenoxy)-phenyl]-propionic acid pentafluorophenyl ester; hydrochloride (120363-48-6) → Methyl (9S,12S,15S)-15-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-12-<(4-hydroxyphenyl)methyl>-11,14-dioxo-2-oxa-10,13-diazatricyclo<15.2.2.13,7>docosa-3,5,7(22),17,19,20-hexaene-9-carboxylate (120363-26-0) + (S)-2-Acetylamino-3-[4-(5-{(S)-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-2-methoxycarbonyl-ethyl}-2-hydroxy-phenoxy)-phenyl]-propionic acid (129213-55-4)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 90 ℃; for 1h;

DOI:10.1021/jo00272a003

Reference yield: 61.0%

(S)-2-((S)-3-{4-[5-((S)-2-Amino-2-methoxycarbonyl-ethyl)-2-hydroxy-phenoxy]-phenyl}-2-tert-butoxycarbonylamino-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid; hydrochloride (120363-51-1) → Methyl (9S,12S,15S)-15-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-12-<(4-hydroxyphenyl)methyl>-11,14-dioxo-2-oxa-10,13-diazatricyclo<15.2.2.13,7>docosa-3,5,7(22),17,19,20-hexaene-9-carboxylate (120363-26-0)

Guidance literature:

With diphenyl phosphoryl azide; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 ℃; for 72h;

DOI:10.1021/jo00311a019

Reference yield: 51.0%

(S)-2-((S)-3-{4-[5-((S)-2-Amino-2-methoxycarbonyl-ethyl)-2-hydroxy-phenoxy]-phenyl}-2-tert-butoxycarbonylamino-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride (120363-52-2) → Methyl (9S,12S,15S)-15-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-12-<(4-hydroxyphenyl)methyl>-11,14-dioxo-2-oxa-10,13-diazatricyclo<15.2.2.13,7>docosa-3,5,7(22),17,19,20-hexaene-9-carboxylate (120363-26-0)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 90 ℃; for 1h;

DOI:10.1021/jo00311a019

upstream raw materials:

(S)-2-((S)-3-{4-[5-((S)-2-Amino-2-methoxycarbonyl-ethyl)-2-hydroxy-phenoxy]-phenyl}-2-tert-butoxycarbonylamino-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid; hydrochloride

(S)-2-((S)-3-{4-[5-((S)-2-Amino-2-methoxycarbonyl-ethyl)-2-hydroxy-phenoxy]-phenyl}-2-tert-butoxycarbonylamino-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride

(S)-2-Acetylamino-3-[4-(5-{(S)-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-2-methoxycarbonyl-ethyl}-2-hydroxy-phenoxy)-phenyl]-propionic acid pentafluorophenyl ester; hydrochloride

di-tert-butyl dicarbonate

Downstream raw materials:

(9S,12S,15S)-15-Amino-4-hydroxy-12-(4-hydroxy-benzyl)-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3⁽²²⁾,4,6,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester; hydrochloride

K-13

Methyl (9S,12S,15S)-15-(acetylamino)-4-hydroxy-12-<(4-hydroxyphenyl)methyl>-11,14-dioxo-2-oxa-10,13-diazatricyclo<15.2.2.1^3,7>docosa-3,5,7(22),17,19,20-hexaene-9-carboxylate

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