4-(4-fluoro-2-(trifluoromethyl)phenyl)piperidine hydrochloride

Base Information

• Chemical Name: 4-(4-fluoro-2-(trifluoromethyl)phenyl)piperidine hydrochloride
• CAS No.: 1004774-99-5
• Molecular Formula: C₁₂H₁₃F₄N*ClH
• Molecular Weight: 283.696
• Mol file: 1004774-99-5.mol

Synonyms:4-(4-fluoro-2-(trifluoromethyl)phenyl)piperidine hydrochloride

Chemical Property of 4-(4-fluoro-2-(trifluoromethyl)phenyl)piperidine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-fluoro-2-(trifluoromethyl)phenyl)piperidine hydrochloride

There total 4 articles about 4-(4-fluoro-2-(trifluoromethyl)phenyl)piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H11F4N*ClH → 4-(4-fluoro-2-(trifluoromethyl)phenyl)piperidine hydrochloride (1004774-99-5)

Guidance literature:

C₁₂H₁₁F₄N*ClH; With platinum(IV) oxide; hydrogen; acetic acid; In ethyl acetate; at 20 ℃; for 72h; under 760.051 Torr;

With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b00352

Reference yield:

4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (138647-49-1) → 4-(4-fluoro-2-(trifluoromethyl)phenyl)piperidine hydrochloride (1004774-99-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 6 h / 80 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; diethyl ether / 18 h / 20 °C / Inert atmosphere

3.1: hydrogen; acetic acid; platinum(IV) oxide / ethyl acetate / 72 h / 20 °C / 760.05 Torr

3.2: 18 h / 20 °C / Inert atmosphere

With hydrogenchloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium carbonate; acetic acid; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; ethyl acetate; 1.1: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.9b00352

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-(4-fluoro-2-(trifluoromethyl)phenyl)piperidine hydrochloride (1004774-99-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

1.2: 3.5 h / -78 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 6 h / 80 °C / Inert atmosphere

3.1: hydrogenchloride / dichloromethane; diethyl ether / 18 h / 20 °C / Inert atmosphere

4.1: hydrogen; acetic acid; platinum(IV) oxide / ethyl acetate / 72 h / 20 °C / 760.05 Torr

4.2: 18 h / 20 °C / Inert atmosphere

With hydrogenchloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium carbonate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; ethyl acetate; 2.1: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.9b00352

upstream raw materials:

4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

N-tert-butyloxycarbonylpiperidin-4-one