ethyl 2-amino-4-methyl-6-(4-methylphenyl)pyrimidine-5-carboxylate

Base Information

• Chemical Name: ethyl 2-amino-4-methyl-6-(4-methylphenyl)pyrimidine-5-carboxylate
• CAS No.: 1395085-48-9
• Molecular Formula: C₁₅H₁₇N₃O₂
• Molecular Weight: 271.319
• Mol file: 1395085-48-9.mol

Synonyms:ethyl 2-amino-4-methyl-6-(4-methylphenyl)pyrimidine-5-carboxylate

Chemical Property of ethyl 2-amino-4-methyl-6-(4-methylphenyl)pyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 2-amino-4-methyl-6-(4-methylphenyl)pyrimidine-5-carboxylate

There total 6 articles about ethyl 2-amino-4-methyl-6-(4-methylphenyl)pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl 4-methyl-6-p-tolyl-2-(tosyloxy)pyrimidine-5-carboxylate (1245716-49-7) → ethyl 2-amino-4-methyl-6-(4-methylphenyl)pyrimidine-5-carboxylate (1395085-48-9)

Guidance literature:

With ammonium hydroxide; at 20 ℃; for 24h; Sealed tube;

DOI:10.1016/j.cclet.2015.01.034

Reference yield: 32.0%

C16H18N4O2 (1395085-50-3) → ethyl 2-amino-4-methyl-6-(4-methylphenyl)pyrimidine-5-carboxylate (1395085-48-9)

Guidance literature:

With manganese(IV) oxide; In o-xylene; for 26h; Reflux;

DOI:10.1007/s10593-012-1034-y

Reference yield:

ethyl 6-methyl-2-oxo-4-p-tolyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (299949-24-9) → ethyl 2-amino-4-methyl-6-(4-methylphenyl)pyrimidine-5-carboxylate (1395085-48-9)

Guidance literature:

With (2,4-dinitro-phenyl)-hydrazine; In dichloromethane; at 80 ℃; for 0.166667h;

DOI:10.1016/j.apcata.2016.06.015

upstream raw materials:

4-methyl-benzaldehyde

C₁₆H₁₈N₄O₂

ethyl acetoacetate

ethyl 4-methyl-6-p-tolyl-2-(tosyloxy)pyrimidine-5-carboxylate