Chromium picolinate

Base Information

• Chemical Name: Chromium picolinate
• CAS No.: 14639-25-9
• Molecular Formula: C18H12CrN3O6
• Molecular Weight: 418.30
• Hs Code.: 29333990
• European Community (EC) Number: 477-680-4,604-524-6
• UNII: S71T8B8Z6P
• DSSTox Substance ID: DTXSID1024831
• Nikkaji Number: J790.269G
• Wikipedia: Chromium(III)_picolinate
• Wikidata: Q2329715
• NCI Thesaurus Code: C28931
• RXCUI: 59308
• Mol file: 14639-25-9.mol

Synonyms:chromium tripicolinate

Chemical Property of Chromium picolinate

Chemical Property:

• Appearance/Colour: violet-red crystalline powder
• Boiling Point: 292.5 °C at 760 mmHg
• Flash Point: 130.7 °C
• PSA: 159.06000
• LogP: -1.66470
• Storage Temp.: room temp
• Solubility.: DMSO (Slightly, Heated)
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 0
• Exact Mass: 418.013115
• Heavy Atom Count: 28
• Complexity: 108

Purity/Quality:

99%, ^*data from raw suppliers

Chromium picolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-36/37/39-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Metals -> Chromium Compounds, Inorganic
• Canonical SMILES: C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].[Cr+3]
• Recent ClinicalTrials: Chromium and Insulin Action
• Chemical Composition: Chromium picolinate exhibits a reddish-pink color. It is a coordination complex composed of chromium(III) and picolinic acid.
• Medical and Nutritional Use: Chromium picolinate is utilized as a nutritional supplement to enhance insulin function, particularly in patients with Type 2 diabetes. It is also used to promote weight loss, as chromium ions help regulate insulin, promote glucose utilization, and increase insulin receptor sensitivity.
• Effects on Hormonal Dysfunctions: Chromium picolinate is categorized among Endocrine Disrupting Compounds (EDCs), potentially impacting testosterone production and male reproductive health. Despite concerns, chromium picolinate supplementation has shown promising effects on human health, particularly in managing blood glucose levels and weight.
• Role in Metabolic Syndrome: Studies indicate that chromium picolinate can alleviate high levels of blood glucose, blood lipids, insulin, and cholesterol in patients with metabolic syndrome. It functions synergistically with insulin produced by the pancreas to metabolize carbohydrates, with picolinic acid aiding in chromium absorption.
• Assimilation Efficiency and Usage: Trivalent chromium, an essential element in mammals for controlling blood glucose, is more efficiently assimilated in organic forms compared to inorganic forms. Chromium picolinate, as an organic chromium supplement, has higher assimilation efficiency (2%鈥?5%) compared to inorganic chromium. However, a significant portion of administered chromium picolinate (around 97.0%) is excreted without change.
• Effect on Broiler Growth: Chromium picolinate is used as a feed additive in broiler diets, showing positive effects on growth performance. Its beneficial effects are observed more efficiently under conditions of environmental, dietary, and hormonal stress.