C₅₃H₆₈N₆O₁₆

Base Information

• Chemical Name: C₅₃H₆₈N₆O₁₆
• CAS No.: 1647150-56-8
• Molecular Formula: C₅₃H₆₈N₆O₁₆
• Molecular Weight: 1045.15
• Mol file: 1647150-56-8.mol

Synonyms:C₅₃H₆₈N₆O₁₆

Chemical Property of C₅₃H₆₈N₆O₁₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₃H₆₈N₆O₁₆

There total 12 articles about C₅₃H₆₈N₆O₁₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

C56H72N6O16 (1647150-55-7) → C53H68N6O16 (1647150-56-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; acetic acid; In N,N-dimethyl-formamide; for 1.5h;

DOI:10.3762/bjoc.10.148

Reference yield:

C33H51N5O11 → C53H68N6O16 (1647150-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / N,N-dimethyl-formamide / 18 h

2: acetic acid; tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.5 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); tri-n-butyl-tin hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.3762/bjoc.10.148

Reference yield:

D-isoGln(Ot-Bu) (70701-78-9) → C53H68N6O16 (1647150-56-8)

Guidance literature:

Multi-step reaction with 6 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.17 h

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4: trimethylphosphane / N,N-dimethyl-formamide; tetrahydrofuran / 3 h

5: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / N,N-dimethyl-formamide / 18 h

6: acetic acid; tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.5 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); tri-n-butyl-tin hydride; benzotriazol-1-ol; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trimethylphosphane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.3762/bjoc.10.148

upstream raw materials:

C₅₆H₇₂N₆O₁₆

D-isoGln(Ot-Bu)

3-azidopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranoside

L-alanyl-D-isoglutamine tert-butyl ester