6-phenyl-6-(2,2,2-trifluoroethyl)tetrahydro-2H-pyran-2-one

Base Information

• Chemical Name: 6-phenyl-6-(2,2,2-trifluoroethyl)tetrahydro-2H-pyran-2-one
• CAS No.: 1537898-07-9
• Molecular Formula: C₁₃H₁₃F₃O₂
• Molecular Weight: 258.24
• Mol file: 1537898-07-9.mol

Synonyms:6-phenyl-6-(2,2,2-trifluoroethyl)tetrahydro-2H-pyran-2-one

Chemical Property of 6-phenyl-6-(2,2,2-trifluoroethyl)tetrahydro-2H-pyran-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6-phenyl-6-(2,2,2-trifluoroethyl)tetrahydro-2H-pyran-2-one

There total 3 articles about 6-phenyl-6-(2,2,2-trifluoroethyl)tetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-phenyl-2-(2,2,2-trifluoroethyl)cyclopentan-1-one → 6-phenyl-6-(2,2,2-trifluoroethyl)tetrahydro-2H-pyran-2-one (1537898-07-9)

Guidance literature:

With magnesium bis(monoperoxyphthalate) hexahydrate; In water; N,N-dimethyl-formamide; at 45 ℃; for 48h; Inert atmosphere;

DOI:10.1002/anie.201503210

Reference yield:

Umemoto's reagent + 5-phenyl-5-pentenoic acid (174708-24-8) → 6-phenyl-6-(2,2,2-trifluoroethyl)tetrahydro-2H-pyran-2-one (1537898-07-9)

Guidance literature:

With dipotassium hydrogenphosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; In acetone; at 20 ℃; for 2.5h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1021/ol403500y

Reference yield:

Umemoto's reagent (129946-88-9) → 6-phenyl-6-(2,2,2-trifluoroethyl)tetrahydro-2H-pyran-2-one (1537898-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate / methanol / 2 h / Schlenk technique; Inert atmosphere

1.2: 6 h / Schlenk technique; Inert atmosphere; Irradiation

2.1: magnesium bis(monoperoxyphthalate) hexahydrate / N,N-dimethyl-formamide; water / 48 h / 45 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; magnesium bis(monoperoxyphthalate) hexahydrate; In methanol; water; N,N-dimethyl-formamide; 2.1: |Baeyer-Villiger Ketone Oxidation;

DOI:10.1002/anie.201503210

upstream raw materials:

5-phenyl-5-pentenoic acid

Umemoto's reagent