(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-((R)-2-(2-((R)-1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

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Chemical Name:(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-((R)-2-(2-((R)-1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate
CAS No.:1315334-28-1
Molecular Formula:C₅₇H₇₀N₄O₇S₃Si
Molecular Weight:1047.49
Hs Code.:

(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-((R)-2-(2-((R)-1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

Synonyms:(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-((R)-2-(2-((R)-1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

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Chemical Property of (S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-((R)-2-(2-((R)-1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

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Technology Process of (S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-((R)-2-(2-((R)-1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

There total 8 articles about (S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-((R)-2-(2-((R)-1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1137735-74-0
(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-amino-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

: 1315334-27-0
(R)-2-(2-((R)-1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxylic acid

: 1315334-28-1
(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-((R)-2-(2-((R)-1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2011.02.024

Reference yield:

: 1315334-26-9
(R)-tert-butyl 1-(4-cyanothiazol-2-yl)-2-phenylethylcarbamate

: 1315334-28-1
(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-((R)-2-(2-((R)-1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / methanol / 2 h / 70 °C / pH 6 / Inert atmosphere; aq. phosphate buffer

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; acetonitrile / 0 - 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2011.02.024

Reference yield:

: C₅₁H₅₇NO₅SSi

: 1315334-28-1
(S,E)-2-(trimethylsilyl)ethyl 3-((S)-2-((R)-2-(2-((R)-1-(tert-butoxycarbonylamino)-2-phenylethyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)-3-methylbutanoyloxy)-7-(tritylthio)hept-4-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamine / acetonitrile / 2 h

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; acetonitrile / 0 - 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2011.02.024