N⁶-benzoyl-8-(hydroxymethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine

Base Information

• Chemical Name: N⁶-benzoyl-8-(hydroxymethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine
• CAS No.: 582295-68-9
• Molecular Formula: C₃₀H₄₃N₅O₆Si
• Molecular Weight: 597.787

Synonyms:N⁶-benzoyl-8-(hydroxymethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine

Chemical Property of N⁶-benzoyl-8-(hydroxymethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine

Chemical Property:

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Technology Process of N⁶-benzoyl-8-(hydroxymethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine

There total 5 articles about N⁶-benzoyl-8-(hydroxymethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + N6-benzoyl-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine (582295-67-8) → N6-benzoyl-8-(hydroxymethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine (582295-68-9)

Guidance literature:

Multistep reaction;

DOI:10.1002/hlca.200490204

Reference yield:

N-[9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-8-formyl-9H-purin-6-yl]-benzamide → N6-benzoyl-8-(hydroxymethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine (582295-68-9)

Guidance literature:

With sodium tetrahydroborate; acetic acid; In ethanol; at 20 ℃;

DOI:10.1039/b300932g

Reference yield:

N-6-benzoyl-2',3'-O-isopropylideneadenosine (39947-04-1) → N6-benzoyl-8-(hydroxymethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine (582295-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 1H-imidazole; DMAP / CH₂Cl₂ / 3 h / 23 °C

With 1H-imidazole; dmap; In dichloromethane;

DOI:10.1002/hlca.200490204

upstream raw materials:

N,N-dimethyl-formamide

N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine

triisopropylsilyl chloride

N-6-benzoyl-2',3'-O-isopropylideneadenosine

Downstream raw materials:

C₆₄H₇₇N₇O₁₄Si

N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

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