Technology Process of (6aS,12bS)-6-(3-nitrobenzyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine
There total 4 articles about (6aS,12bS)-6-(3-nitrobenzyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
iron (III) chloride hexahydrate;
In
dichloromethane;
at 60 - 65 ℃;
for 24h;
enantioselective reaction;
DOI:10.1021/ol2008236
- Guidance literature:
-
Multi-step reaction with 3 steps
1: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; C32H42FeP2(1+) / tetrahydrofuran / 24 h / 60 °C / Inert atmosphere
2: sodium acetate; toluene-4-sulfonic acid hydrazide / tetrahydrofuran; water / 20 h / Reflux
3: iron (III) chloride hexahydrate / dichloromethane / 24 h / 60 - 65 °C
With
bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; iron (III) chloride hexahydrate; C32H42FeP2(1+); sodium acetate; toluene-4-sulfonic acid hydrazide;
In
tetrahydrofuran; dichloromethane; water;
3: Friedel Crafts alkylation;
DOI:10.1021/ol2008236
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium acetate; toluene-4-sulfonic acid hydrazide / tetrahydrofuran; water / 20 h / Reflux
2: iron (III) chloride hexahydrate / dichloromethane / 24 h / 60 - 65 °C
With
iron (III) chloride hexahydrate; sodium acetate; toluene-4-sulfonic acid hydrazide;
In
tetrahydrofuran; dichloromethane; water;
2: Friedel Crafts alkylation;
DOI:10.1021/ol2008236
