(S)-3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy propionic acid

Base Information

Chemical Name:(S)-3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy propionic acid
CAS No.:401789-88-6
Molecular Formula:C₂₈H₂₇NO₅
Molecular Weight:457.526
Hs Code.:

Synonyms:(S)-3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy propionic acid

Suppliers and Price of (S)-3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy propionic acid

Chemical Property:

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Technology Process of (S)-3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy propionic acid

There total 12 articles about (S)-3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 401790-94-1
3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy-propionic Acid Ethyl Ester

: 401789-88-6
(S)-3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy propionic acid

Guidance literature:: With sodium hydroxide; In ethanol; Heating;
DOI:10.1016/j.bmcl.2004.09.031

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 401789-88-6
(S)-3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / LDA / -78 °C

2: 100 percent / pyridine / CH₂Cl₂

3: 90 percent / H₂ / Pd/C / ethyl acetate

4: 70 percent / Cs₂CO₃ / dimethylformamide / 55 °C

5: 99 percent / aq. NaOH / ethanol / Heating

With pyridine; sodium hydroxide; hydrogen; caesium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.09.031

Reference yield:

: 42412-84-0
ethyl 2-phenoxypropionate

: 401789-88-6
(S)-3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / LDA / -78 °C

2: 100 percent / pyridine / CH₂Cl₂

3: 90 percent / H₂ / Pd/C / ethyl acetate

4: 70 percent / Cs₂CO₃ / dimethylformamide / 55 °C

5: 99 percent / aq. NaOH / ethanol / Heating

With pyridine; sodium hydroxide; hydrogen; caesium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.09.031