(S)-1-(4-{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol

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Chemical Name:(S)-1-(4-{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol
CAS No.:1232398-89-8
Molecular Formula:C₂₆H₃₀N₆O₂
Molecular Weight:458.563
Hs Code.:

Synonyms:(S)-1-(4-{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol

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Chemical Property of (S)-1-(4-{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol

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Technology Process of (S)-1-(4-{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol

There total 8 articles about (S)-1-(4-{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232816-20-4
7-(2-methoxyphenyl)-2-(methylsulfinyl)pyrrolo[2,1-f][1,2,4]triazine

: 1232816-24-8
(S)-1-(4-(4-aminophenyl)piperazin-1-yl)propan-2-ol

: 1232398-89-8
(S)-1-(4-{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 2-methoxy-ethanol; at 180 ℃; for 0.666667h; Microwave irradiation;

Reference yield:

: 1233181-87-7
7-(2-methoxy-phenyl)-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine

: 1232398-89-8
(S)-1-(4-{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

2: water; sodium hydroxide / 100 °C

3: N-ethyl-N,N-diisopropylamine / 1-methoxy-2-propanol

4: 1-methoxy-2-propanol / 50 °C

With water; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In 1-methoxy-2-propanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.10.032

Reference yield:

: 1232816-20-4
7-(2-methoxyphenyl)-2-(methylsulfinyl)pyrrolo[2,1-f][1,2,4]triazine

: 1232398-89-8
(S)-1-(4-{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / 100 °C

2: N-ethyl-N,N-diisopropylamine / 1-methoxy-2-propanol

3: 1-methoxy-2-propanol / 50 °C

With water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1-methoxy-2-propanol;
DOI:10.1016/j.bmcl.2011.10.032