3-chloro-4'-((R)-1-{[3-(9H-fluoren-9-ylmethoxycarbonylamino)-oxetane-3-carbonyl]-amino}-ethyl)-3'-fluoro-biphenyl-2-carboxylic acid methyl ester

Base Information

Chemical Name:3-chloro-4'-((R)-1-{[3-(9H-fluoren-9-ylmethoxycarbonylamino)-oxetane-3-carbonyl]-amino}-ethyl)-3'-fluoro-biphenyl-2-carboxylic acid methyl ester
CAS No.:1384171-62-3
Molecular Formula:C₃₅H₃₀ClFN₂O₆
Molecular Weight:629.084
Hs Code.:

Synonyms:3-chloro-4'-((R)-1-{[3-(9H-fluoren-9-ylmethoxycarbonylamino)-oxetane-3-carbonyl]-amino}-ethyl)-3'-fluoro-biphenyl-2-carboxylic acid methyl ester

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Chemical Property of 3-chloro-4'-((R)-1-{[3-(9H-fluoren-9-ylmethoxycarbonylamino)-oxetane-3-carbonyl]-amino}-ethyl)-3'-fluoro-biphenyl-2-carboxylic acid methyl ester

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Technology Process of 3-chloro-4'-((R)-1-{[3-(9H-fluoren-9-ylmethoxycarbonylamino)-oxetane-3-carbonyl]-amino}-ethyl)-3'-fluoro-biphenyl-2-carboxylic acid methyl ester

There total 10 articles about 3-chloro-4'-((R)-1-{[3-(9H-fluoren-9-ylmethoxycarbonylamino)-oxetane-3-carbonyl]-amino}-ethyl)-3'-fluoro-biphenyl-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (1R)-1-[3'-chloro-3-fluoro-2'-(methoxycarbonyl)-1,1'-biphenyl-4-yl]ethanamine hydrochloride

: 1380327-56-9
3-(9H-fluoren-9-ylmethoxycarbonylamino)oxetane-3-carboxylic acid

: 1384171-62-3
3-chloro-4'-((R)-1-{[3-(9H-fluoren-9-ylmethoxycarbonylamino)-oxetane-3-carbonyl]-amino}-ethyl)-3'-fluoro-biphenyl-2-carboxylic acid methyl ester

Guidance literature:: 3-(9H-fluoren-9-ylmethoxycarbonylamino)oxetane-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(1R)-1-[3'-chloro-3-fluoro-2'-(methoxycarbonyl)-1,1'-biphenyl-4-yl]ethanamine hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 57848-46-1
4-bromo-2-fluorobenzaldehyde

: 1384171-62-3
3-chloro-4'-((R)-1-{[3-(9H-fluoren-9-ylmethoxycarbonylamino)-oxetane-3-carbonyl]-amino}-ethyl)-3'-fluoro-biphenyl-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: magnesium sulfate; pyridinium p-toluenesulfonate / dichloromethane / 20 °C

2.1: dichloromethane; diethyl ether / 6 h / -48 °C

3.1: hydrogenchloride / 1,4-dioxane; methanol / 4 h

4.1: triethylamine / dichloromethane / 20 h / 0 - 20 °C

5.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dichloromethane; dimethyl sulfoxide / 50 h / 90 °C

6.1: potassium carbonate / palladium diacetate; tris-(o-tolyl)phosphine / water; tetrahydrofuran / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

8.2: 20 °C

With hydrogenchloride; potassium acetate; pyridinium p-toluenesulfonate; magnesium sulfate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 6.1: Suzuki Coupling;

Reference yield:

: 845829-92-7
tert-butyl (1R)-1-(4-bromo-2-fluorophenyl)ethylcarbamate

: 1384171-62-3
3-chloro-4'-((R)-1-{[3-(9H-fluoren-9-ylmethoxycarbonylamino)-oxetane-3-carbonyl]-amino}-ethyl)-3'-fluoro-biphenyl-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dichloromethane; dimethyl sulfoxide / 50 h / 90 °C

2.1: potassium carbonate / palladium diacetate; tris-(o-tolyl)phosphine / water; tetrahydrofuran / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 20 °C

With hydrogenchloride; potassium acetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: Suzuki Coupling;