(S,R_S)-tert-butyl 3-(2-bromophenyl)-3-(1,1-dimethylethylsulfinamido)propanoate

Base Information

• Chemical Name: (S,R_S)-tert-butyl 3-(2-bromophenyl)-3-(1,1-dimethylethylsulfinamido)propanoate
• CAS No.: 1609692-19-4
• Molecular Formula: C₁₇H₂₆BrNO₃S
• Molecular Weight: 404.368
• Mol file: 1609692-19-4.mol

Synonyms:(S,R_S)-tert-butyl 3-(2-bromophenyl)-3-(1,1-dimethylethylsulfinamido)propanoate

Chemical Property of (S,R_S)-tert-butyl 3-(2-bromophenyl)-3-(1,1-dimethylethylsulfinamido)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,R_S)-tert-butyl 3-(2-bromophenyl)-3-(1,1-dimethylethylsulfinamido)propanoate

There total 1 articles about (S,R_S)-tert-butyl 3-(2-bromophenyl)-3-(1,1-dimethylethylsulfinamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

bromoacetic acid tert-butyl ester (5292-43-3) + (R)-N-(2-bromobenzyliden)-N-(tert-butanesulfinyl)amine (1015198-51-2) → (S,RS)-tert-butyl 3-(2-bromophenyl)-3-(1,1-dimethylethylsulfinamido)propanoate (1609692-19-4)

Guidance literature:

bromoacetic acid tert-butyl ester; With zinc; In tetrahydrofuran; at 20 ℃; for 0.5h; Reflux; Inert atmosphere;

(R)-N-(2-bromobenzyliden)-N-(tert-butanesulfinyl)amine; In tetrahydrofuran; at 20 ℃; stereoselective reaction; Inert atmosphere;

DOI:10.1039/c4cc01831a

Reference yield: 94.0%

(S,RS)-tert-butyl 3-(2-bromophenyl)-3-(1,1-dimethylethylsulfinamido)propanoate (1609692-19-4) → tert-butyl (S)-3-(2-bromophenyl)-3-aminopropanoate

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 1h;

DOI:10.1039/c4cc01831a

upstream raw materials:

bromoacetic acid tert-butyl ester

(R)-N-(2-bromobenzyliden)-N-(tert-butanesulfinyl)amine