methyl 3-methyl-2-{N-[3-(2-{3-[(4-methylbenzene)sulfonyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}(2-⁽²⁾H)butanoate

Base Information

• Chemical Name: methyl 3-methyl-2-{N-[3-(2-{3-[(4-methylbenzene)sulfonyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}(2-⁽²⁾H)butanoate
• CAS No.: 1362825-66-8
• Molecular Formula: C₃₂H₃₃NO₆S₂
• Molecular Weight: 592.741

Synonyms:methyl 3-methyl-2-{N-[3-(2-{3-[(4-methylbenzene)sulfonyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}(2-⁽²⁾H)butanoate

Chemical Property of methyl 3-methyl-2-{N-[3-(2-{3-[(4-methylbenzene)sulfonyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}(2-⁽²⁾H)butanoate

Chemical Property:

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Technology Process of methyl 3-methyl-2-{N-[3-(2-{3-[(4-methylbenzene)sulfonyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}(2-⁽²⁾H)butanoate

There total 7 articles about methyl 3-methyl-2-{N-[3-(2-{3-[(4-methylbenzene)sulfonyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}(2-⁽²⁾H)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H32(2)HNO4S2 → methyl 3-methyl-2-{N-[3-(2-{3-[(4-methylbenzene)sulfonyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}(2-(2)H)butanoate (1362825-66-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1021/jo202580y

Reference yield:

1-iodo-2-(3-iodoprop-1-ynyl)benzene (1253043-95-6) → methyl 3-methyl-2-{N-[3-(2-{3-[(4-methylbenzene)sulfonyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}(2-(2)H)butanoate (1362825-66-8)

Guidance literature:

Multi-step reaction with 5 steps

1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 4.75 h / 40 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.67 h / 0 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo202580y

Reference yield:

C25H26(2)HNO5S → methyl 3-methyl-2-{N-[3-(2-{3-[(4-methylbenzene)sulfonyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}(2-(2)H)butanoate (1362825-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.67 h / 0 °C / Inert atmosphere

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/jo202580y

upstream raw materials:

1-iodo-2-(3-iodoprop-1-ynyl)benzene

methyl 3-methyl-2-[(4-methylbenzene)sulfonamido](2-⁽²⁾H)butanoate

(±)-methyl 3-methyl-2-(4-methylphenylsulfonamido)butanoate

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