1-Aethyl-6-(4-nitroanilino)-4,5,8-trioxo-1,4,5,8-tetrahydro-3-chinolincarbonsaeure

Base Information

Chemical Name:1-Aethyl-6-(4-nitroanilino)-4,5,8-trioxo-1,4,5,8-tetrahydro-3-chinolincarbonsaeure
CAS No.:85525-82-2
Molecular Formula:C₁₈H₁₃N₃O₇
Molecular Weight:383.317
Hs Code.:

Synonyms:1-Aethyl-6-(4-nitroanilino)-4,5,8-trioxo-1,4,5,8-tetrahydro-3-chinolincarbonsaeure

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Chemical Property of 1-Aethyl-6-(4-nitroanilino)-4,5,8-trioxo-1,4,5,8-tetrahydro-3-chinolincarbonsaeure

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Technology Process of 1-Aethyl-6-(4-nitroanilino)-4,5,8-trioxo-1,4,5,8-tetrahydro-3-chinolincarbonsaeure

There total 16 articles about 1-Aethyl-6-(4-nitroanilino)-4,5,8-trioxo-1,4,5,8-tetrahydro-3-chinolincarbonsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 100-01-6,104810-17-5
4-nitro-aniline

: 85525-57-1
1-ethyl-4,5,8-trioxo-1,4,5,8-tetrahydroquinolin-3-carboxylic acid

: 85525-56-0
1-Aethyl-5,8-dihydroxy-4-oxo-1,4-dihydro-3-chinolincarbonsaeure

: 85525-82-2
1-Aethyl-6-(4-nitroanilino)-4,5,8-trioxo-1,4,5,8-tetrahydro-3-chinolincarbonsaeure

Guidance literature:: In methanol; acetic acid; for 20h;
DOI:10.1002/hlca.19820650835

Reference yield:

: 102-56-7,102526-87-4
2,5-dimethoxyaniline

: 85525-82-2
1-Aethyl-6-(4-nitroanilino)-4,5,8-trioxo-1,4,5,8-tetrahydro-3-chinolincarbonsaeure

Guidance literature:: Multi-step reaction with 6 steps

1: 86.2 percent / dioxane / 20 h / 50 °C

2: 51.7 percent / Dowtherm A / 0.5 h / Heating

3: 1.) NaH / 1.) DMF, 50 deg C, 2 h; 2.) DMF, 50 deg C, 22 h

4: 85.9 percent / KOH, H₂O / 16 h / Ambient temperature

5: 86 percent / cerium(IV)ammonium nitrate / acetonitrile; H₂O / 0.5 h / 0 °C

6: 60 percent / methanol; acetic acid / 20 h

With potassium hydroxide; diphenyl ether-biphenyl eutectic; ammonium cerium(IV) nitrate; water; sodium hydride; In 1,4-dioxane; methanol; water; acetic acid; acetonitrile;
DOI:10.1002/hlca.19820650835

Reference yield:

: 621-91-0
1,4-dibenzyloxybenzene

: 85525-82-2
1-Aethyl-6-(4-nitroanilino)-4,5,8-trioxo-1,4,5,8-tetrahydro-3-chinolincarbonsaeure

Guidance literature:: Multi-step reaction with 8 steps

1: 93.9 percent / HNO₃ / acetic acid / 0.5 h / 30 °C

2: 97.6 percent / H₂ / Raney-Ni / ethyl acetate / 3 h / 23 °C / 75.01 Torr

3: 85.4 percent / H₂ / Raney-Ni / ethyl acetate

4: 51.9 percent / dioxane / 3 h / Heating

5: 73 percent / HF / 72 h / Ambient temperature

6: 57 percent / 1N HCl / acetic acid / 4 h / 50 °C

7: 54.5 percent / cerium(IV)ammonium nitrate / acetonitrile; H₂O; CHCl₃ / 0.17 h

8: 60 percent / methanol; acetic acid / 20 h

With hydrogenchloride; ammonium cerium(IV) nitrate; hydrogen fluoride; hydrogen; nitric acid; nickel; In 1,4-dioxane; methanol; chloroform; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1002/hlca.19820650835