2,3-Piperazinedione, 1,4-bis((4-(2-pyrimidinylamino)phenyl)methyl)-

Base Information

Chemical Name:2,3-Piperazinedione, 1,4-bis((4-(2-pyrimidinylamino)phenyl)methyl)-
CAS No.:77917-10-3
Molecular Formula:C₂₆H₂₄N₈O₂
Molecular Weight:480.529
Hs Code.:
DSSTox Substance ID:DTXSID70228552
Wikidata:Q83108546

Synonyms:BRN 5675766;2,3-Piperazinedione, 1,4-bis((4-(2-pyrimidinylamino)phenyl)methyl)-;1,4-Bis(4-(2-pyrimidinylamino)benzyl)-2,3-dioxopiperazine;1,4-Bis((4-(2-pyrimidinylamino)phenyl)methyl)-2,3-piperazinedione;77917-10-3;1,4-bis[4-(2-pyrimidinylamino)benzyl]-2,3-dioxopiperazine;SCHEMBL11050060;DTXSID70228552;INJBZDXWCTXPTI-UHFFFAOYSA-N;C26H24N8O2;C26-H24-N8-O2;LS-111860

Suppliers and Price of 2,3-Piperazinedione, 1,4-bis((4-(2-pyrimidinylamino)phenyl)methyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,3-Piperazinedione, 1,4-bis((4-(2-pyrimidinylamino)phenyl)methyl)-

Chemical Property:

Vapor Pressure:8.5E-22mmHg at 25°C
Boiling Point:740.5°C at 760 mmHg
Flash Point:401.7°C
Density:1.4g/cm³
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:480.20222204
Heavy Atom Count:36
Complexity:651

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(C(=O)C(=O)N1CC2=CC=C(C=C2)NC3=NC=CC=N3)CC4=CC=C(C=C4)NC5=NC=CC=N5

Technology Process of 2,3-Piperazinedione, 1,4-bis((4-(2-pyrimidinylamino)phenyl)methyl)-

There total 3 articles about 2,3-Piperazinedione, 1,4-bis((4-(2-pyrimidinylamino)phenyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.1%

: 77917-09-0
1,4-bis(4-aminobenzyl)-2,3-dioxopiperazine

: 4595-60-2
2-bromopyrimidine

: 77917-10-3
1,4-bis<4-(2-pyrimidinylamino)benzyl>-2,3-dioxopiperazine

Guidance literature:: In N,N-dimethyl-formamide; for 2h; Heating;
DOI:10.1248/cpb.29.1253

Reference yield:

: 77917-07-8
N,N'-dibenzyl-2,3-diketopiperazine

: 77917-10-3
1,4-bis<4-(2-pyrimidinylamino)benzyl>-2,3-dioxopiperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / cc HNO₃, cc H₂SO₄ / 0 deg C, 1 h, RT, 11 h

2: 46.9 percent / Zn powder, CaCl₂ / ethanol; H₂O / 2 h / Heating

3: 44.1 percent / dimethylformamide / 2 h / Heating

With sulfuric acid; nitric acid; calcium chloride; zinc; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.1253

Reference yield:

: 77917-08-9
1,4-bis(4-nitrobenzyl)-2,3-dioxopiperazine

: 77917-10-3
1,4-bis<4-(2-pyrimidinylamino)benzyl>-2,3-dioxopiperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 46.9 percent / Zn powder, CaCl₂ / ethanol; H₂O / 2 h / Heating

2: 44.1 percent / dimethylformamide / 2 h / Heating

With calcium chloride; zinc; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.1253