1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile

Base Information

Chemical Name:1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile
CAS No.:1056263-55-8
Molecular Formula:C₂₁H₁₄FN₃O₂
Molecular Weight:359.359
Hs Code.:

Synonyms:1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile

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Chemical Property of 1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile

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Technology Process of 1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile

There total 3 articles about 1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1056263-48-9
4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazole-6-carbonitrile

: 1056263-55-8
1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile

Guidance literature:: 4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazole-6-carbonitrile; With potassium hydroxide; water; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In 1,4-dioxane; at 90 ℃; for 1h;

With hydrogenchloride; water; In 1,4-dioxane; ethyl acetate; at 20 ℃; pH=7;

Reference yield:

: 898746-96-8
4-bromo-1H-indazole-6-carbonitrile

: 1056263-55-8
1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / copper diacetate / dichloromethane / 144 h / 20 °C / Molecular sieve

2.1: potassium hydroxide; water / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane / 1 h / 90 °C

2.2: 20 °C / pH 7

With pyridine; potassium hydroxide; water; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper diacetate; tert-butyl XPhos; In 1,4-dioxane; dichloromethane;

Reference yield:

: 133057-83-7
4-benzyloxy-3-fluorophenylboronic acid

: 1056263-55-8
1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indazole-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / copper diacetate / dichloromethane / 144 h / 20 °C / Molecular sieve

2.1: potassium hydroxide; water / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane / 1 h / 90 °C

2.2: 20 °C / pH 7

With pyridine; potassium hydroxide; water; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper diacetate; tert-butyl XPhos; In 1,4-dioxane; dichloromethane;