(2S,3R)-3-amino-2-hydroxy-5-methyl-1-phenylhexane

Base Information

Chemical Name:(2S,3R)-3-amino-2-hydroxy-5-methyl-1-phenylhexane
CAS No.:115205-99-7
Molecular Formula:C₁₃H₂₁NO
Molecular Weight:207.316
Hs Code.:

Synonyms:(2S,3R)-3-amino-2-hydroxy-5-methyl-1-phenylhexane

Suppliers and Price of (2S,3R)-3-amino-2-hydroxy-5-methyl-1-phenylhexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-3-amino-2-hydroxy-5-methyl-1-phenylhexane

Chemical Property:

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Technology Process of (2S,3R)-3-amino-2-hydroxy-5-methyl-1-phenylhexane

There total 9 articles about (2S,3R)-3-amino-2-hydroxy-5-methyl-1-phenylhexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 115205-97-5
(4R,5S)-4-(benzylamino)-5-hydroxy-2-methyl-6-phenyl-1-hexene

: 115205-99-7
(2S,3R)-3-amino-2-hydroxy-5-methyl-1-phenylhexane

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr;
DOI:10.1021/jo00251a042

Reference yield:

: 20312-36-1
L-3-phenyllactic acid

: 115205-99-7
(2S,3R)-3-amino-2-hydroxy-5-methyl-1-phenylhexane

Guidance literature:: Multi-step reaction with 9 steps

1: 92 percent / conc. HCl / toluene / 4 h / Heating

2: 92 percent / toluene / 4 h / Heating

3: 1.) DIBAH, 2.) conc. HCl / 1.) toluene, hexane, 40 min, 2.) RT, 4 h

4: 86.3 percent / TiCl₄ / CH₂Cl₂ / 12 h / 0 - 20 °C

5: 50percent NaOH / ethanol / 10 h / Heating

6: 95 percent / Et₃N / CH₂Cl₂ / 4 h

7: 88 percent / SOCl₂ / CH₂Cl₂ / 10 h / Ambient temperature

8: 88 percent / 50percent NaOH / ethanol / 10 h / Heating

9: 80 percent / H₂ / 10percent Pd-C / ethanol / 760 Torr

With hydrogenchloride; sodium hydroxide; thionyl chloride; hydrogen; titanium tetrachloride; diisobutylaluminium hydride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; toluene;
DOI:10.1021/jo00251a042

Reference yield:

: 13673-95-5
(S)-methyl 2-hydroxy-3-phenylpropanoate

: 115205-99-7
(2S,3R)-3-amino-2-hydroxy-5-methyl-1-phenylhexane

Guidance literature:: Multi-step reaction with 8 steps

1: 92 percent / toluene / 4 h / Heating

2: 1.) DIBAH, 2.) conc. HCl / 1.) toluene, hexane, 40 min, 2.) RT, 4 h

3: 86.3 percent / TiCl₄ / CH₂Cl₂ / 12 h / 0 - 20 °C

4: 50percent NaOH / ethanol / 10 h / Heating

5: 95 percent / Et₃N / CH₂Cl₂ / 4 h

6: 88 percent / SOCl₂ / CH₂Cl₂ / 10 h / Ambient temperature

7: 88 percent / 50percent NaOH / ethanol / 10 h / Heating

8: 80 percent / H₂ / 10percent Pd-C / ethanol / 760 Torr

With hydrogenchloride; sodium hydroxide; thionyl chloride; hydrogen; titanium tetrachloride; diisobutylaluminium hydride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; toluene;
DOI:10.1021/jo00251a042