α-N-benzyloxycarbonyl-β-(2,5-dimethoxyphenyl)tryptophan tert-butyl ester

Base Information

Chemical Name:α-N-benzyloxycarbonyl-β-(2,5-dimethoxyphenyl)tryptophan tert-butyl ester
CAS No.:296235-56-8
Molecular Formula:C₃₁H₃₄N₂O₆
Molecular Weight:530.621
Hs Code.:

Synonyms:α-N-benzyloxycarbonyl-β-(2,5-dimethoxyphenyl)tryptophan tert-butyl ester

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Chemical Property of α-N-benzyloxycarbonyl-β-(2,5-dimethoxyphenyl)tryptophan tert-butyl ester

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Technology Process of α-N-benzyloxycarbonyl-β-(2,5-dimethoxyphenyl)tryptophan tert-butyl ester

There total 4 articles about α-N-benzyloxycarbonyl-β-(2,5-dimethoxyphenyl)tryptophan tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 296235-47-7
2-tert-butoxycarbonyl-3-(2,5-dimethoxyphenyl)-3-(indol-3-yl)-propionic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 296235-56-8
α-N-benzyloxycarbonyl-β-(2,5-dimethoxyphenyl)tryptophan tert-butyl ester

Guidance literature:: 2-tert-butoxycarbonyl-3-(2,5-dimethoxyphenyl)-3-(indol-3-yl)-propionic acid; With diphenyl-phosphinic acid; triethylamine; In toluene; at 110 ℃; for 2h;

benzyl alcohol; In toluene; at 110 ℃;
DOI:10.1016/S0040-4020(00)00446-4

Reference yield:

: 67996-13-8
5-<(2,5-dimethoxyphenyl)-1H-indol-3-ylmethyl>-2,2-dimethyl-1,3-dioxane-4,6-dione

: 296235-56-8
α-N-benzyloxycarbonyl-β-(2,5-dimethoxyphenyl)tryptophan tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / pyridine / 1.5 h / Heating

2.1: DPPA; Et₃N / toluene / 2 h / 110 °C

2.2: 90 percent / toluene / 110 °C

With diphenyl-phosphinic acid; triethylamine; In pyridine; toluene; 1.1: Ring cleavage / 2.1: Rearrangement / 2.2: Addition;
DOI:10.1016/S0040-4020(00)00446-4

Reference yield:

: 120-72-9
indole

: 296235-56-8
α-N-benzyloxycarbonyl-β-(2,5-dimethoxyphenyl)tryptophan tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / D,L-proline / acetonitrile / 15 h / 20 °C

2.1: 96 percent / pyridine / 1.5 h / Heating

3.1: DPPA; Et₃N / toluene / 2 h / 110 °C

3.2: 90 percent / toluene / 110 °C

With diphenyl-phosphinic acid; triethylamine; rac-Pro-OH; In pyridine; toluene; acetonitrile; 1.1: Condensation / 2.1: Ring cleavage / 3.1: Rearrangement / 3.2: Addition;
DOI:10.1016/S0040-4020(00)00446-4