Acetic acid 4-((E)-2-{(1S,2S)-2-[(E)-3-(4-acetoxy-phenyl)-acryloylamino]-cyclohexylcarbamoyl}-vinyl)-phenyl ester

Base Information

• Chemical Name: Acetic acid 4-((E)-2-{(1S,2S)-2-[(E)-3-(4-acetoxy-phenyl)-acryloylamino]-cyclohexylcarbamoyl}-vinyl)-phenyl ester
• CAS No.: 184866-89-5
• Molecular Formula: C₂₈H₃₀N₂O₆
• Molecular Weight: 490.556
• Mol file: 184866-89-5.mol

Synonyms:Acetic acid 4-((E)-2-{(1S,2S)-2-[(E)-3-(4-acetoxy-phenyl)-acryloylamino]-cyclohexylcarbamoyl}-vinyl)-phenyl ester

Chemical Property of Acetic acid 4-((E)-2-{(1S,2S)-2-[(E)-3-(4-acetoxy-phenyl)-acryloylamino]-cyclohexylcarbamoyl}-vinyl)-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid 4-((E)-2-{(1S,2S)-2-[(E)-3-(4-acetoxy-phenyl)-acryloylamino]-cyclohexylcarbamoyl}-vinyl)-phenyl ester

There total 3 articles about Acetic acid 4-((E)-2-{(1S,2S)-2-[(E)-3-(4-acetoxy-phenyl)-acryloylamino]-cyclohexylcarbamoyl}-vinyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-Coumaric Acid (7400-08-0,50940-26-6) → Acetic acid 4-((E)-2-{(1S,2S)-2-[(E)-3-(4-acetoxy-phenyl)-acryloylamino]-cyclohexylcarbamoyl}-vinyl)-phenyl ester (184866-89-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / pyridine / 12 h / Ambient temperature

2: SOCl₂ / 3 h / Heating

3: (4-dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; dmap; thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/0957-4166(96)00372-2

Reference yield:

4-acetoxycinnamic acid (27542-85-4) → Acetic acid 4-((E)-2-{(1S,2S)-2-[(E)-3-(4-acetoxy-phenyl)-acryloylamino]-cyclohexylcarbamoyl}-vinyl)-phenyl ester (184866-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 3 h / Heating

2: (4-dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With dmap; thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/0957-4166(96)00372-2

Reference yield:

p-acetoxycinnamoyl chloride (53901-95-4,108608-06-6,58523-18-5) + (S,S)-1,2-diaminocyclohexane (21436-03-3) → Acetic acid 4-((E)-2-{(1S,2S)-2-[(E)-3-(4-acetoxy-phenyl)-acryloylamino]-cyclohexylcarbamoyl}-vinyl)-phenyl ester (184866-89-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 12h; Yield given; Ambient temperature;

DOI:10.1016/0957-4166(96)00372-2

upstream raw materials:

p-acetoxycinnamoyl chloride

(S,S)-1,2-diaminocyclohexane

p-Coumaric Acid

4-acetoxycinnamic acid