S-(4,4'-dimethoxytrityl)-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine

Base Information

Chemical Name:S-(4,4'-dimethoxytrityl)-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine
CAS No.:1373406-39-3
Molecular Formula:C₃₅H₃₆N₂O₁₀S
Molecular Weight:676.744
Hs Code.:

Synonyms:S-(4,4'-dimethoxytrityl)-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine

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Chemical Property of S-(4,4'-dimethoxytrityl)-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine

Chemical Property:

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Technology Process of S-(4,4'-dimethoxytrityl)-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine

There total 4 articles about S-(4,4'-dimethoxytrityl)-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₈N₂O₈S

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1373406-39-3
S-(4,4'-dimethoxytrityl)-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.02.024

Reference yield:

: 42855-00-5
nitroveratryloxycarbonyl chloride

: 1373406-39-3
S-(4,4'-dimethoxytrityl)-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 17 h / 20 °C / Inert atmosphere

1.2: pH 4

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 23 h / 20 °C / Inert atmosphere

4.1: lithium hydroxide / methanol; water / 1 h / 20 °C / Inert atmosphere

4.2: pH Ca_. 3

5.1: triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; lithium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.02.024

Reference yield:

: 1067427-07-9
N-(6-nitroveratryloxycarbonyl)-L-allo-threonine

: 1373406-39-3
S-(4,4'-dimethoxytrityl)-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 23 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide / methanol; water / 1 h / 20 °C / Inert atmosphere

3.2: pH Ca_. 3

4.1: triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; lithium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.02.024