methyl (6R,9R,12R)-12-benzyl-6-isopropyl-2,2,9-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

Base Information

• Chemical Name: methyl (6R,9R,12R)-12-benzyl-6-isopropyl-2,2,9-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate
• CAS No.: 1093111-81-9
• Molecular Formula: C₂₃H₃₅N₃O₆
• Molecular Weight: 449.547

Synonyms:methyl (6R,9R,12R)-12-benzyl-6-isopropyl-2,2,9-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

Chemical Property of methyl (6R,9R,12R)-12-benzyl-6-isopropyl-2,2,9-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

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Technology Process of methyl (6R,9R,12R)-12-benzyl-6-isopropyl-2,2,9-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

There total 1 articles about methyl (6R,9R,12R)-12-benzyl-6-isopropyl-2,2,9-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Boc-D-Val-OH (22838-58-0) + D-Ala-D-Phe-OMe (313503-79-6) → methyl (6R,9R,12R)-12-benzyl-6-isopropyl-2,2,9-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate (1093111-81-9)

Guidance literature:

Boc-D-Val-OH; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

D-Ala-D-Phe-OMe; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo8020264

Reference yield: 93.0%

methyl (6R,9R,12R)-12-benzyl-6-isopropyl-2,2,9-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate (1093111-81-9) → (6R,9R,12R)-12-benzyl-6-isopropyl-2,2,9-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid (1093111-82-0)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 0 ℃; for 6h;

DOI:10.1021/jo8020264

upstream raw materials:

Boc-D-Val-OH

D-Ala-D-Phe-OMe

Downstream raw materials:

(6R,9R,12R)-12-benzyl-6-isopropyl-2,2,9-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid

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