Technology Process of C12H18IN3O3S
There total 1 articles about C12H18IN3O3S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
ethanol;
Inert atmosphere;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: methanesulfonic acid / acetone / 25 °C / Cooling with ice
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 °C
3: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1 h / 100 °C
4: acetonitrile / 100 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; methanesulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
1,4-dioxane; dichloromethane; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: methanesulfonic acid
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 50 - 100 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane
4: tetraethylammonium fluoride / acetonitrile
5: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 1,4-dioxane / 50 - 100 °C
6: acetonitrile / Reflux
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; methanesulfonic acid; tetraethylammonium fluoride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
1,4-dioxane; dichloromethane; acetonitrile;
5: Sonogashira coupling;
DOI:10.1016/j.bmcl.2012.06.021
