6-(tetrahydro-pyran-2-yl)-2-(4-trifluoromethyl-phenyl)-6H-selenolo[2,3-d]pyridazin-7-one

Base Information

Chemical Name:6-(tetrahydro-pyran-2-yl)-2-(4-trifluoromethyl-phenyl)-6H-selenolo[2,3-d]pyridazin-7-one
CAS No.:935509-46-9
Molecular Formula:C₁₈H₁₅F₃N₂O₂Se
Molecular Weight:427.285
Hs Code.:

6-(tetrahydro-pyran-2-yl)-2-(4-trifluoromethyl-phenyl)-6<i>H</i>-selenolo[2,3-<i>d</i>]pyridazin-7-one

Synonyms:6-(tetrahydro-pyran-2-yl)-2-(4-trifluoromethyl-phenyl)-6H-selenolo[2,3-d]pyridazin-7-one

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Chemical Property of 6-(tetrahydro-pyran-2-yl)-2-(4-trifluoromethyl-phenyl)-6H-selenolo[2,3-d]pyridazin-7-one

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Technology Process of 6-(tetrahydro-pyran-2-yl)-2-(4-trifluoromethyl-phenyl)-6H-selenolo[2,3-d]pyridazin-7-one

There total 6 articles about 6-(tetrahydro-pyran-2-yl)-2-(4-trifluoromethyl-phenyl)-6H-selenolo[2,3-d]pyridazin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 868662-14-0
4-chloro-2-(tetrahydropyran-2-yl)-5-(4-trifluoromethylphenylethynyl)-2H-pyridazin-3-one

: 935509-46-9
6-(tetrahydro-pyran-2-yl)-2-(4-trifluoromethyl-phenyl)-6H-selenolo[2,3-d]pyridazin-7-one

Guidance literature:: With selenium; sodium tetrahydroborate; In N,N-dimethyl-formamide; for 0.333333h; cooling;
DOI:10.1021/jm051263c

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 935509-46-9
6-(tetrahydro-pyran-2-yl)-2-(4-trifluoromethyl-phenyl)-6H-selenolo[2,3-d]pyridazin-7-one

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / TsOH / tetrahydrofuran / Heating

2: 83 percent / KOH

3: 75 percent / aq. KOH / Heating

4: TEA / CH₂Cl₂ / 0.5 h / 0 °C

5: 467 mg / Pd(PPh₃)2Cl₂; CuI; tetra-n-butylammonium iodide / TEA / tetrahydrofuran / 3 h

6: 34 percent / Se; NaBH₄ / dimethylformamide / 0.33 h / cooling

With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; selenium; sodium tetrahydroborate; copper(l) iodide; TEA; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid; TEA; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 5: Sonogashira coupling;
DOI:10.1021/jm051263c

Reference yield:

: 868662-13-9
trifluoro-methanesulfonic acid 5-chloro-6-oxo-1-(tetrahydro-pyran-2-yl)-1,6-dihydro-pyridazin-4-yl ester

: 935509-46-9
6-(tetrahydro-pyran-2-yl)-2-(4-trifluoromethyl-phenyl)-6H-selenolo[2,3-d]pyridazin-7-one

Guidance literature:: Multi-step reaction with 2 steps

1: 467 mg / Pd(PPh₃)2Cl₂; CuI; tetra-n-butylammonium iodide / TEA / tetrahydrofuran / 3 h

2: 34 percent / Se; NaBH₄ / dimethylformamide / 0.33 h / cooling

With bis-triphenylphosphine-palladium(II) chloride; selenium; sodium tetrahydroborate; copper(l) iodide; tetra-(n-butyl)ammonium iodide; TEA; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1021/jm051263c