2-(2-((4′-methoxy-[1,1′-biphenyl]-4-yl)sulfonyl)phenyl)acetohydroxamic acid

Base Information

Chemical Name:2-(2-((4′-methoxy-[1,1′-biphenyl]-4-yl)sulfonyl)phenyl)acetohydroxamic acid
CAS No.:1191112-04-5
Molecular Formula:C₂₁H₁₉NO₅S
Molecular Weight:397.452
Hs Code.:

Synonyms:2-(2-((4′-methoxy-[1,1′-biphenyl]-4-yl)sulfonyl)phenyl)acetohydroxamic acid

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Chemical Property of 2-(2-((4′-methoxy-[1,1′-biphenyl]-4-yl)sulfonyl)phenyl)acetohydroxamic acid

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Technology Process of 2-(2-((4′-methoxy-[1,1′-biphenyl]-4-yl)sulfonyl)phenyl)acetohydroxamic acid

There total 5 articles about 2-(2-((4′-methoxy-[1,1′-biphenyl]-4-yl)sulfonyl)phenyl)acetohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: ethyl 2-(2-((4′-methoxy-[1,1′-biphenyl]-4-yl)sulfonyl)phenyl)acetate

: 1191112-04-5
2-(2-((4′-methoxy-[1,1′-biphenyl]-4-yl)sulfonyl)phenyl)acetohydroxamic acid

Guidance literature:: With hydroxylamine; potassium hydroxide; In methanol; at 20 ℃; for 16h; pH=9; Cooling with ice;
DOI:10.1021/acs.jmedchem.8b00096

Reference yield:

: C₂₇H₃₃NO₅SSi

: 1191112-04-5
2-(2-((4′-methoxy-[1,1′-biphenyl]-4-yl)sulfonyl)phenyl)acetohydroxamic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃;
DOI:10.1021/jm900335a

Reference yield:

: 13420-80-9
[2-(4-bromo-phenylsulfanyl)phenyl]acetic acid

: 1191112-04-5
2-(2-((4′-methoxy-[1,1′-biphenyl]-4-yl)sulfonyl)phenyl)acetohydroxamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 4 h / 60 °C

2: palladium diacetate; triphenylphosphine; sodium carbonate / water; toluene; ethanol / 2 h / 100 °C / Inert atmosphere

3: potassium peroxymonosulfate sulfate / water; methanol; tetrahydrofuran / 48 h / 0 - 20 °C

4: hydroxylamine; potassium hydroxide / methanol / 16 h / 20 °C / pH 9 / Cooling with ice

With thionyl chloride; potassium peroxymonosulfate sulfate; hydroxylamine; palladium diacetate; sodium carbonate; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; water; toluene; 2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.8b00096