methyl 3-(4-{[1-(3-ethoxyphenyl)-2-(2,4-difluorophenyl)-1H-imidazol-4-yl]carbonyl}-1-piperazinyl)-1-naphthoate

Base Information

Chemical Name:methyl 3-(4-{[1-(3-ethoxyphenyl)-2-(2,4-difluorophenyl)-1H-imidazol-4-yl]carbonyl}-1-piperazinyl)-1-naphthoate
CAS No.:954398-14-2
Molecular Formula:C₃₄H₃₀F₂N₄O₄
Molecular Weight:596.633
Hs Code.:

Synonyms:methyl 3-(4-{[1-(3-ethoxyphenyl)-2-(2,4-difluorophenyl)-1H-imidazol-4-yl]carbonyl}-1-piperazinyl)-1-naphthoate

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Chemical Property of methyl 3-(4-{[1-(3-ethoxyphenyl)-2-(2,4-difluorophenyl)-1H-imidazol-4-yl]carbonyl}-1-piperazinyl)-1-naphthoate

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Technology Process of methyl 3-(4-{[1-(3-ethoxyphenyl)-2-(2,4-difluorophenyl)-1H-imidazol-4-yl]carbonyl}-1-piperazinyl)-1-naphthoate

There total 1 articles about methyl 3-(4-{[1-(3-ethoxyphenyl)-2-(2,4-difluorophenyl)-1H-imidazol-4-yl]carbonyl}-1-piperazinyl)-1-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(3-ethoxyphenyl)-2-(2,4-difluorophenyl)-1H-imidazole-4-carboxylic acid

: 954397-86-5
methyl 3-(1-piperazinyl)-1-naphthoate trifluoroacetate

: 954398-14-2
methyl 3-(4-{[1-(3-ethoxyphenyl)-2-(2,4-difluorophenyl)-1H-imidazol-4-yl]carbonyl}-1-piperazinyl)-1-naphthoate

Guidance literature:: 1-(3-ethoxyphenyl)-2-(2,4-difluorophenyl)-1H-imidazole-4-carboxylic acid; With 1-methyl-1H-imidazole; methanesulfonyl chloride; In dichloromethane; at 0 ℃; for 0.75h;

methyl 3-(1-piperazinyl)-1-naphthoate trifluoroacetate; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 954398-14-2
methyl 3-(4-{[1-(3-ethoxyphenyl)-2-(2,4-difluorophenyl)-1H-imidazol-4-yl]carbonyl}-1-piperazinyl)-1-naphthoate

: 76-05-1
trifluoroacetic acid

: 954398-12-0
3-(4-{[1-(3-ethoxyphenyl)-2-(2,4-difluorophenyl)-1H-imidazol-4-yl]carbonyl}-1-piperazinyl)-1-naphthoic acid trifluoroacetate

Guidance literature:: methyl 3-(4-{[1-(3-ethoxyphenyl)-2-(2,4-difluorophenyl)-1H-imidazol-4-yl]carbonyl}-1-piperazinyl)-1-naphthoate; With methanol; lithium hydroxide; water; In tetrahydrofuran; for 2h;

With hydrogenchloride; water; In tetrahydrofuran; methanol; ethyl acetate;

trifluoroacetic acid; In water; N,N-dimethyl-formamide; acetonitrile;