4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)-3-fluorobenzoic acid hydrochloride

Base Information

Chemical Name:4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)-3-fluorobenzoic acid hydrochloride
CAS No.:603123-88-2
Molecular Formula:C₂₅H₂₃ClFNO₃*ClH
Molecular Weight:476.375
Hs Code.:

Synonyms:4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)-3-fluorobenzoic acid hydrochloride

Suppliers and Price of 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)-3-fluorobenzoic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)-3-fluorobenzoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)-3-fluorobenzoic acid hydrochloride

There total 13 articles about 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)-3-fluorobenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2788-86-5,53649-47-1,97466-49-4,21019-51-2
(R)-2-(4-chlorophenyl)oxirane

: 603123-88-2
4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)-3-fluorobenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 18 h / Reflux

2: tetrahydrofuran / 12 h / 20 °C

3: 2,6-dimethylpyridine / dichloromethane / -78 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 20 - 80 °C / Inert atmosphere

5: methanol; sodium hydroxide; water / 20 °C

6: hydrogenchloride / 1,4-dioxane / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; methanol; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 4: Suzuki coupling;
DOI:10.1021/jm800222k

Reference yield:

: 603124-11-4
C₃₀H₃₁ClFNO₅

: 603123-88-2
4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)-3-fluorobenzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/jm800222k

Reference yield:

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 603123-88-2
4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)-3-fluorobenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: AD-mixβ; water / tert-butyl alcohol / 4 h / Cooling with ice

2: Trimethyl orthoacetate; chloro-trimethyl-silane / dichloromethane / 1 h / Cooling with ice

3: ethanol / 18 h / Reflux

4: tetrahydrofuran / 12 h / 20 °C

5: 2,6-dimethylpyridine / dichloromethane / -78 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 20 - 80 °C / Inert atmosphere

7: methanol; sodium hydroxide; water / 20 °C

8: hydrogenchloride / 1,4-dioxane / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; methanol; Trimethyl orthoacetate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro-trimethyl-silane; AD-mixβ; water; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; tert-butyl alcohol; 6: Suzuki coupling;
DOI:10.1021/jm800222k