(+)-tert-butyl [(1S)-2-(1,3-benzodioxol-5-yl)-1-(iodomethyl)ethyl]benzylcarbamate

Base Information

Chemical Name:(+)-tert-butyl [(1S)-2-(1,3-benzodioxol-5-yl)-1-(iodomethyl)ethyl]benzylcarbamate
CAS No.:929885-96-1
Molecular Formula:C₂₂H₂₆INO₄
Molecular Weight:495.357
Hs Code.:

Synonyms:(+)-tert-butyl [(1S)-2-(1,3-benzodioxol-5-yl)-1-(iodomethyl)ethyl]benzylcarbamate

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Chemical Property of (+)-tert-butyl [(1S)-2-(1,3-benzodioxol-5-yl)-1-(iodomethyl)ethyl]benzylcarbamate

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Technology Process of (+)-tert-butyl [(1S)-2-(1,3-benzodioxol-5-yl)-1-(iodomethyl)ethyl]benzylcarbamate

There total 3 articles about (+)-tert-butyl [(1S)-2-(1,3-benzodioxol-5-yl)-1-(iodomethyl)ethyl]benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 929885-95-0
(-)-tert-butyl [(1S)-2-(1,3-benzodioxol-5-yl)-1-(hydroxymethyl)ethyl]benzylcarbamate

: 929885-96-1
(+)-tert-butyl [(1S)-2-(1,3-benzodioxol-5-yl)-1-(iodomethyl)ethyl]benzylcarbamate

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1002/hlca.200790006

Reference yield:

: 929885-93-8
(2S,3R)-3-(1,3-benzodioxol-5-yl)-1-benzyl-aziridine-2-carboxylic acid tert-butyl ester

: 929885-96-1
(+)-tert-butyl [(1S)-2-(1,3-benzodioxol-5-yl)-1-(iodomethyl)ethyl]benzylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / H₂ / Pd(OH)2/C / methanol / 6.5 h / 20 °C

2: 88 percent / LiBH₄ / tetrahydrofuran; ethanol / 17 h / Heating

3: 66 percent / PPh₃; I₂; 1H-imidazole / CH₂Cl₂ / 3 h / 20 °C

With 1H-imidazole; lithium borohydride; hydrogen; iodine; triphenylphosphine; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1002/hlca.200790006

Reference yield:

: 929885-94-9
(+)-tert-butyl (2S)-3-(1,3-benzodioxol-5-yl)-2-{(benzyl)[(tert-butoxy)carbonyl]amino}propanoate

: 929885-96-1
(+)-tert-butyl [(1S)-2-(1,3-benzodioxol-5-yl)-1-(iodomethyl)ethyl]benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / LiBH₄ / tetrahydrofuran; ethanol / 17 h / Heating

2: 66 percent / PPh₃; I₂; 1H-imidazole / CH₂Cl₂ / 3 h / 20 °C

With 1H-imidazole; lithium borohydride; iodine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/hlca.200790006