5-(2,4-dihydroxy-5-isopropyl-benzoyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid (2-chloro-ethyl)-amide

Base Information

Chemical Name:5-(2,4-dihydroxy-5-isopropyl-benzoyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid (2-chloro-ethyl)-amide
CAS No.:1584301-73-4
Molecular Formula:C₁₉H₂₂ClN₃O₅
Molecular Weight:407.854
Hs Code.:

Synonyms:5-(2,4-dihydroxy-5-isopropyl-benzoyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid (2-chloro-ethyl)-amide

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Chemical Property of 5-(2,4-dihydroxy-5-isopropyl-benzoyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid (2-chloro-ethyl)-amide

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Technology Process of 5-(2,4-dihydroxy-5-isopropyl-benzoyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid (2-chloro-ethyl)-amide

There total 8 articles about 5-(2,4-dihydroxy-5-isopropyl-benzoyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid (2-chloro-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1584301-96-1
C₃₃H₃₄ClN₃O₅

: 1584301-73-4
5-(2,4-dihydroxy-5-isopropyl-benzoyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid (2-chloro-ethyl)-amide

Guidance literature:: With boron trichloride; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1016/j.ejmech.2014.01.056

Reference yield:

: 1584301-90-5
ethyl 5-(2,4-bis(benzyloxy)-5-isopropylbenzoyl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carboxylate

: 1584301-73-4
5-(2,4-dihydroxy-5-isopropyl-benzoyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid (2-chloro-ethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / water; tetrahydrofuran

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C

3: boron trichloride / dichloromethane / 0.5 h / -78 °C

With lithium hydroxide monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; boron trichloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.ejmech.2014.01.056

Reference yield:

: 1584301-67-6
5-(2,4-bis-(benzyloxy)-5-isopropylbenzoyl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carboxylic acid

: 1584301-73-4
5-(2,4-dihydroxy-5-isopropyl-benzoyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid (2-chloro-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C

2: boron trichloride / dichloromethane / 0.5 h / -78 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; boron trichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.ejmech.2014.01.056