2-(4-chlorophenyl)-5-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one

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Chemical Name:2-(4-chlorophenyl)-5-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one
CAS No.:1224172-04-6
Molecular Formula:C₂₇H₃₄ClN₃O₅Si
Molecular Weight:544.123
Hs Code.:

Synonyms:2-(4-chlorophenyl)-5-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one

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Chemical Property of 2-(4-chlorophenyl)-5-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one

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Technology Process of 2-(4-chlorophenyl)-5-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one

There total 7 articles about 2-(4-chlorophenyl)-5-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1224172-03-5
4-(chloromethyl)-1-(4-chlorophenyl)-N-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-1H-pyrazole-3-carboxamide

: 1224172-04-6
2-(4-chlorophenyl)-5-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: C₂₈H₃₈ClN₃O₈SSi

: 1224172-04-6
2-(4-chlorophenyl)-5-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2015.05.008

Reference yield:

: C₁₅H₁₂Cl₂N₂O₂

: 1224172-04-6
2-(4-chlorophenyl)-5-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / isopropyl alcohol / 2 h / 80 °C

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4.5 h / 20 °C

4: lithium borohydride / tetrahydrofuran / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

With lithium borohydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2015.05.008