4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-phenoxythiocarbonyl-7H-pyrrolo<2,3-d>pyrimidine

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Chemical Name:4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-phenoxythiocarbonyl-7H-pyrrolo<2,3-d>pyrimidine
CAS No.:119447-94-8
Molecular Formula:C₃₉H₃₄ClN₃O₆S
Molecular Weight:708.234
Hs Code.:

Synonyms:4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-phenoxythiocarbonyl-7H-pyrrolo<2,3-d>pyrimidine

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Chemical Property of 4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-phenoxythiocarbonyl-7H-pyrrolo<2,3-d>pyrimidine

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Technology Process of 4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-phenoxythiocarbonyl-7H-pyrrolo<2,3-d>pyrimidine

There total 6 articles about 4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-phenoxythiocarbonyl-7H-pyrrolo<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 119447-93-7
4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo<2,3-d>pyrimidine

: 1005-56-7
phenylcarbonochloridothioate

: 119447-94-8
4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-phenoxythiocarbonyl-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:: With dmap; In acetonitrile; for 16h; Ambient temperature;
DOI:10.1055/s-1988-27667

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 119447-94-8
4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-phenoxythiocarbonyl-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KOH / 1.) tris-<2-(2-methoxyethoxy)ethyl>amine / 1.) MeCN, room temp., 5 min, 2.) room temp., 15 min

2: 84 percent / NH₃ / methanol / 24 h / Ambient temperature

3: 78 percent / pyridine, N,N-diisopropylethylamine / 3 h / Ambient temperature

4: 76 percent / 4-dimethylaminopyridine / acetonitrile / 16 h / Ambient temperature

With pyridine; dmap; potassium hydroxide; ammonia; N-ethyl-N,N-diisopropylamine; Tris(3,6-dioxaheptyl)amine; In methanol; acetonitrile;
DOI:10.1055/s-1988-27667

Reference yield:

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 119447-94-8
4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-phenoxythiocarbonyl-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KOH / 1.) tris-<2-(2-methoxyethoxy)ethyl>amine / 1.) MeCN, room temp., 5 min, 2.) room temp., 15 min

2: 84 percent / NH₃ / methanol / 24 h / Ambient temperature

3: 78 percent / pyridine, N,N-diisopropylethylamine / 3 h / Ambient temperature

4: 76 percent / 4-dimethylaminopyridine / acetonitrile / 16 h / Ambient temperature

With pyridine; dmap; potassium hydroxide; ammonia; N-ethyl-N,N-diisopropylamine; Tris(3,6-dioxaheptyl)amine; In methanol; acetonitrile;
DOI:10.1055/s-1988-27667