[4-chloro-2-(4-methylpiperazin-1-yl)-3-phenylquinolin-6-yl](1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

Base Information

Chemical Name:[4-chloro-2-(4-methylpiperazin-1-yl)-3-phenylquinolin-6-yl](1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate
CAS No.:1600563-67-4
Molecular Formula:C₂HF₃O₂*C₃₀H₂₉ClN₆O
Molecular Weight:639.077
Hs Code.:

Synonyms:[4-chloro-2-(4-methylpiperazin-1-yl)-3-phenylquinolin-6-yl](1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

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Chemical Property of [4-chloro-2-(4-methylpiperazin-1-yl)-3-phenylquinolin-6-yl](1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

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Technology Process of [4-chloro-2-(4-methylpiperazin-1-yl)-3-phenylquinolin-6-yl](1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

There total 11 articles about [4-chloro-2-(4-methylpiperazin-1-yl)-3-phenylquinolin-6-yl](1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1600563-62-9
(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(pyridin-4-yl)methanol

: 76-05-1
trifluoroacetic acid

: 1600563-67-4
[4-chloro-2-(4-methylpiperazin-1-yl)-3-phenylquinolin-6-yl](1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

Guidance literature:: 1-methyl-piperazine; (2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(pyridin-4-yl)methanol; In methanol; at 80 ℃; for 30.5h;

trifluoroacetic acid; In methanol; at 80 ℃; for 22h;

Reference yield:

: 1600562-94-4
(1-methyl-1H-imidazol-5-yl)(pyridin-4-yl)methanone

: 1600563-67-4
[4-chloro-2-(4-methylpiperazin-1-yl)-3-phenylquinolin-6-yl](1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.17 h / -78 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: methanol / 30.5 h / 80 °C

2.2: 22 h / 80 °C

With n-butyllithium; In tetrahydrofuran; methanol; hexane;

Reference yield:

: 452349-62-1
methyl 5-bromo-2-(2-phenylacetamido)benzoate

: 1600563-67-4
[4-chloro-2-(4-methylpiperazin-1-yl)-3-phenylquinolin-6-yl](1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane; water / 4 h / -78 - 20 °C

2.1: trichlorophosphate / 3.5 h / 107 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.17 h / -78 °C / Inert atmosphere

3.3: 20 °C / Inert atmosphere

4.1: methanol / 30.5 h / 80 °C

4.2: 22 h / 80 °C

With n-butyllithium; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; methanol; hexane; water;