4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl-cyanamide

Base Information

Chemical Name:4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl-cyanamide
CAS No.:1076690-69-1
Molecular Formula:C₂₀H₁₉ClN₄O₃
Molecular Weight:398.849
Hs Code.:

Synonyms:4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl-cyanamide

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Chemical Property of 4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl-cyanamide

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Technology Process of 4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl-cyanamide

There total 4 articles about 4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl-cyanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 506-68-3
bromocyane

: 1076690-59-9
1-[3-(4-amino-phenyl)-4,5-dihydro-pyrazol-1-yl]-2-(2-chloro-4,5-dimethoxy-phenyl)-ethanone

: 1076690-69-1
4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl-cyanamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 72.3333h;

Reference yield:

: 2898-63-7
2-(2-chloro-4,5-dimethoxyphenyl)acetic acid

: 1076690-69-1
4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl-cyanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2.62 h / 0 - 20 °C

1.2: 1.5 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / acetonitrile / 17.5 h / 20 °C

3.1: triethylamine / dichloromethane / 72.33 h / 20 °C

With oxalyl dichloride; hydrogen; triethylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 1076690-69-1
4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl-cyanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxone(R); potassium chloride / water; acetonitrile / 1 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2.62 h / 0 - 20 °C

2.2: 1.5 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / acetonitrile / 17.5 h / 20 °C

4.1: triethylamine / dichloromethane / 72.33 h / 20 °C

With oxone(R); oxalyl dichloride; potassium chloride; hydrogen; triethylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In dichloromethane; water; acetonitrile;