Methanesulfonic acid (3R,4R)-1,4-dibenzyl-pyrrolidin-3-yl ester

Base Information

• Chemical Name: Methanesulfonic acid (3R,4R)-1,4-dibenzyl-pyrrolidin-3-yl ester
• CAS No.: 218431-67-5
• Molecular Formula: C₁₉H₂₃NO₃S
• Molecular Weight: 345.463
• Mol file: 218431-67-5.mol

Synonyms:Methanesulfonic acid (3R,4R)-1,4-dibenzyl-pyrrolidin-3-yl ester

Chemical Property of Methanesulfonic acid (3R,4R)-1,4-dibenzyl-pyrrolidin-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (3R,4R)-1,4-dibenzyl-pyrrolidin-3-yl ester

There total 1 articles about Methanesulfonic acid (3R,4R)-1,4-dibenzyl-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methanesulfonate(3R,4R)-1,1,3-tribenzyl-4-methanesulfonyloxy-pyrrolidinium; → Methanesulfonic acid (3R,4R)-1,4-dibenzyl-pyrrolidin-3-yl ester (218431-67-5)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; Yield given; Ambient temperature;

DOI:10.1016/S0960-894X(98)00507-1

Reference yield: 27.0%

sodium cyanide (143-33-9,25596-52-5) + Methanesulfonic acid (3R,4R)-1,4-dibenzyl-pyrrolidin-3-yl ester (218431-67-5) → (3S,4S)-1,4-Dibenzyl-pyrrolidine-3-carbonitrile (218431-68-6)

Guidance literature:

With 18-crown-6 ether; In dimethyl sulfoxide; at 50 ℃; for 168h;

DOI:10.1016/S0960-894X(98)00507-1

Reference yield: 25.0%

Methanesulfonic acid (3R,4R)-1,4-dibenzyl-pyrrolidin-3-yl ester (218431-67-5) → 1,3-dibenzyl-2,3-dihydropyrrole

Guidance literature:

With 18-crown-6 ether; sodium cyanide; In dimethyl sulfoxide; at 50 ℃; for 168h;

DOI:10.1016/S0960-894X(98)00507-1

Downstream raw materials:

(3S,4S)-1,4-Dibenzyl-pyrrolidine-3-carbonitrile

(3S,4S)-1,4-Dibenzyl-pyrrolidine-3-carboxylic acid

(3S,4S)-1,4-Dibenzyl-pyrrolidine-3-carboxylic acid [(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide

{(S)-2-[((3S,4S)-1,4-Dibenzyl-pyrrolidine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-acetic acid ethyl ester