(S)-4-fluoro-N-(2-((4-(hydroxycarbamoyl)phenyl)amino)-2-oxo-1-phenylethyl)benzamide

Base Information

Chemical Name:(S)-4-fluoro-N-(2-((4-(hydroxycarbamoyl)phenyl)amino)-2-oxo-1-phenylethyl)benzamide
CAS No.:1446014-65-8
Molecular Formula:C₂₂H₁₈FN₃O₄
Molecular Weight:407.401
Hs Code.:

Synonyms:(S)-4-fluoro-N-(2-((4-(hydroxycarbamoyl)phenyl)amino)-2-oxo-1-phenylethyl)benzamide

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Chemical Property of (S)-4-fluoro-N-(2-((4-(hydroxycarbamoyl)phenyl)amino)-2-oxo-1-phenylethyl)benzamide

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Technology Process of (S)-4-fluoro-N-(2-((4-(hydroxycarbamoyl)phenyl)amino)-2-oxo-1-phenylethyl)benzamide

There total 7 articles about (S)-4-fluoro-N-(2-((4-(hydroxycarbamoyl)phenyl)amino)-2-oxo-1-phenylethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1587675-56-6
(S)-methyl 4-(2-(4-fluorobenzamido)-2-phenylacetamido)benzoate

: 1446014-65-8
(S)-4-fluoro-N-(2-((4-(hydroxycarbamoyl)phenyl)amino)-2-oxo-1-phenylethyl)benzamide

Guidance literature:: With hydroxylamine potassium salt; In methanol; at 20 ℃; for 2h;
DOI:10.1002/cmdc.201300297

Reference yield:

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 1446014-65-8
(S)-4-fluoro-N-(2-((4-(hydroxycarbamoyl)phenyl)amino)-2-oxo-1-phenylethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 8 h / 25 °C

2: ethyl acetate; hydrogenchloride / 5 h / 25 °C

3: sodium hydrogencarbonate / water; tetrahydrofuran / 8 h / 20 °C

4: hydroxylamine potassium salt / methanol / 2 h / 20 °C

With hydrogenchloride; hydroxylamine potassium salt; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ethyl acetate; triethylamine; In tetrahydrofuran; methanol; water;
DOI:10.1002/cmdc.201300297

Reference yield:

: 2935-35-5
(S)-2-phenylglycine

: 1446014-65-8
(S)-4-fluoro-N-(2-((4-(hydroxycarbamoyl)phenyl)amino)-2-oxo-1-phenylethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / methanol; water / 8 h / 25 °C

2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 8 h / 25 °C

3: ethyl acetate; hydrogenchloride / 5 h / 25 °C

4: sodium hydrogencarbonate / water; tetrahydrofuran / 8 h / 20 °C

5: hydroxylamine potassium salt / methanol / 2 h / 20 °C

With hydrogenchloride; hydroxylamine potassium salt; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ethyl acetate; triethylamine; In tetrahydrofuran; methanol; water;
DOI:10.1002/cmdc.201300297