1-Methoxy-4-((E)-(2R,5S,7S)-7-methoxy-2,8-dimethyl-5-triisopropylsilanyloxy-9-trimethylsilanyl-non-8-enyloxymethyl)-benzene

Base Information

Chemical Name:1-Methoxy-4-((E)-(2R,5S,7S)-7-methoxy-2,8-dimethyl-5-triisopropylsilanyloxy-9-trimethylsilanyl-non-8-enyloxymethyl)-benzene
CAS No.:168777-77-3
Molecular Formula:C₃₂H₆₀O₄Si₂
Molecular Weight:564.997
Hs Code.:

Synonyms:1-Methoxy-4-((E)-(2R,5S,7S)-7-methoxy-2,8-dimethyl-5-triisopropylsilanyloxy-9-trimethylsilanyl-non-8-enyloxymethyl)-benzene

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Chemical Property of 1-Methoxy-4-((E)-(2R,5S,7S)-7-methoxy-2,8-dimethyl-5-triisopropylsilanyloxy-9-trimethylsilanyl-non-8-enyloxymethyl)-benzene

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Technology Process of 1-Methoxy-4-((E)-(2R,5S,7S)-7-methoxy-2,8-dimethyl-5-triisopropylsilanyloxy-9-trimethylsilanyl-non-8-enyloxymethyl)-benzene

There total 10 articles about 1-Methoxy-4-((E)-(2R,5S,7S)-7-methoxy-2,8-dimethyl-5-triisopropylsilanyloxy-9-trimethylsilanyl-non-8-enyloxymethyl)-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 168777-76-2
(E)-(3S,5S,8R)-3-Methoxy-9-(4-methoxy-benzyloxy)-2,8-dimethyl-1-trimethylsilanyl-non-1-en-5-ol

: 168777-77-3
1-Methoxy-4-((E)-(2R,5S,7S)-7-methoxy-2,8-dimethyl-5-triisopropylsilanyloxy-9-trimethylsilanyl-non-8-enyloxymethyl)-benzene

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.333333h;
DOI:10.1039/c39930000617

Reference yield:

: 6224-91-5
trimethyl(prop-1-ynyl)silane

: 168777-77-3
1-Methoxy-4-((E)-(2R,5S,7S)-7-methoxy-2,8-dimethyl-5-triisopropylsilanyloxy-9-trimethylsilanyl-non-8-enyloxymethyl)-benzene

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) n-Bu₃SnH, 2.) I₂ / 1.) 3CN)2> / 1.) THF, 25 deg C, 30 min, 2.) CH₂Cl₂, 0 deg C, 15 min

2: 62 percent / t-BuLi / diethyl ether; pentane / 1.) -78 deg C, 30 min, 2.) -78 deg C, 1.5 h

3: 86 percent / LiI, LiAlH₄ / diethyl ether / 1.) r.t., 30 min, 2.) -100 deg C, 10 min

4: 97 percent / NaH / dimethylformamide / 1.) 25 deg C, 30 min, 2.) 25 deg C, 40 min

5: CSA, MeOH / 3 h / 25 °C

6: Et₃N / CH₂Cl₂ / 0.42 h / 0 °C

7: K₂CO₃ / methanol / 2 h / 25 °C

8: 1.) t-BuLi, lithium 2-thienylcyanocuprate / 1.) Et₂O, pentane, -98 deg C, 30 min; THF, 0 deg C, 5 min, 2.) 0 deg C, 1.5 h

9: 94 percent / 2,6-lutidine / CH₂Cl₂ / 0.17 h / 0 °C

With 2,6-dimethylpyridine; methanol; lithium aluminium tetrahydride; camphor-10-sulfonic acid; iodine; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium hydride; potassium carbonate; thien-2-yl(cyano)copper lithium; triethylamine; lithium iodide; ; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; pentane;

Reference yield:

: 148933-46-4
[(E)-(S)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methoxy-2-methyl-but-1-enyl]-trimethyl-silane

: 168777-77-3
1-Methoxy-4-((E)-(2R,5S,7S)-7-methoxy-2,8-dimethyl-5-triisopropylsilanyloxy-9-trimethylsilanyl-non-8-enyloxymethyl)-benzene

Guidance literature:: Multi-step reaction with 5 steps

1: CSA, MeOH / 3 h / 25 °C

2: Et₃N / CH₂Cl₂ / 0.42 h / 0 °C

3: K₂CO₃ / methanol / 2 h / 25 °C

4: 1.) t-BuLi, lithium 2-thienylcyanocuprate / 1.) Et₂O, pentane, -98 deg C, 30 min; THF, 0 deg C, 5 min, 2.) 0 deg C, 1.5 h

5: 94 percent / 2,6-lutidine / CH₂Cl₂ / 0.17 h / 0 °C

With 2,6-dimethylpyridine; methanol; camphor-10-sulfonic acid; tert.-butyl lithium; potassium carbonate; thien-2-yl(cyano)copper lithium; triethylamine; In methanol; dichloromethane;