2,2'-Furoin

Base Information

• Chemical Name: 2,2'-Furoin
• CAS No.: 552-86-3
• Deprecated CAS: 92921-36-3
• Molecular Formula: C10H8 O4
• Molecular Weight: 192.171
• Hs Code.: 2932190090
• European Community (EC) Number: 209-024-8
• NSC Number: 18522,6105
• UNII: FP41RNB020
• DSSTox Substance ID: DTXSID60862181
• Nikkaji Number: J6.723G
• Wikipedia: Furoin
• Wikidata: Q5509696
• ChEMBL ID: CHEMBL364893
• Mol file: 552-86-3.mol

Synonyms:Furoin(6CI,7CI,8CI); (?à)-Furoin;1,2-Bis(2-furyl)-2-hydroxyethanone; 2-Furyl(hydroxy)methyl 2-furyl ketone; NSC18522; NSC 6105; a-Furoin

Chemical Property of 2,2'-Furoin

Chemical Property:

• Appearance/Colour: LIGHT YELLOW TO LIGHT BROWN AMORPHOUS POWDER
• Vapor Pressure: 0.000328mmHg at 25°C
• Melting Point: 134-137 °C
• Refractive Index: 1.4440 (estimate)
• Boiling Point: 306.8 °C at 760 mmHg
• PKA: 11.62±0.20(Predicted)
• Flash Point: 139.4 °C
• PSA: 63.58000
• Density: 1.32 g/cm
• LogP: 1.78890
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: acetone: soluble0.25g/10 mL, clear, colorless to deep brown-yell
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 192.04225873
• Heavy Atom Count: 14
• Complexity: 216

Purity/Quality:

98%,99%, ^*data from raw suppliers

Furoin ^*data from reagent suppliers

Safty Information:

• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Other Organic Compounds
• Canonical SMILES: C1=COC(=C1)C(C(=O)C2=CC=CO2)O
• Uses: Furoin was used as fluorogenic reagent for the selective and sensitive liquid chromatographic determination of various guanidines.

Technology Process of 2,2'-Furoin

There total 26 articles about 2,2'-Furoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

furfural (98-01-1) → furoin (552-86-3)

Guidance literature:

With triethylamine; In neat (no solvent); at 80 ℃; for 3h; Reagent/catalyst; Temperature; Solvent; Catalytic behavior; Sealed tube; Inert atmosphere; Green chemistry;

DOI:10.1039/c6ra14594a

Reference yield: 90.0%

furfural (98-01-1) → furil (492-94-4) + furoin (552-86-3)

Guidance literature:

With potassium tert-butylate; 1-n-octyl-3-methylimidazolium iodide; In tetrahydrofuran; at 24 ℃; Inert atmosphere;

DOI:10.1002/adsc.201000308

Reference yield: 87.0%

β-furoin oxime (21659-48-3) → furoin (552-86-3)

Guidance literature:

With manganese triacetate; In benzene; for 1h; Heating;

DOI:10.1016/S0040-4039(97)01688-2

upstream raw materials:

furfural

potassium cyanide

furil

1,2-di-[2]furyl-2-hydroxy-3-morpholino-propan-1-one

Downstream raw materials:

bis-(2-nitro-stilben-4-yl)-diazene-N-oxide

2-p-toluidino-1,2-bis-[2]furyl-ethanone

2,3-di-furan-2-yl-quinoxaline

furil

Refernces

• 1、 Yan, Bing,Zang, Hongjun,Jiang, Yi,Yu, Songbai,Chen, Eugene Y.-X.. "Recyclable montmorillonite-supported thiazolium ionic liquids for high-yielding and solvent-free upgrading of furfural and 5-hydroxymethylfurfural to C10 and C12 furoins". . p. 76707 - 76715. Retrieved 2016.
• 2、 Dinjar, Kristijan,Djerdj, Igor,Koj?inovi?, Jelena,Kukovecz, ákos,Markovi?, Berislav,Mileti?, Aleksandar,Nagy, Sándor Balázs,Sapi, Andras,Stenzel, David,Széchenyi, Aleksandar,Szenti, Imre,Tang, Yushu,Tatar, Dalibor,Varga, Gábor,Ziegenheim, Szilveszter. "Sol-gel synthesis of ceria-zirconia-based high-entropy oxides as high-promotion catalysts for the synthesis of 1,2-diketones from aldehyde". . . Retrieved 2021/10/20.
• 3、 Deng, Chen-Qiang,Jiang, Qin-Zhu,Deng, Jin,Fu, Yao. "Synthesis of 1,10-decanediol diacetate and 1-decanol acetate from furfural". supporting information. p. 2169 - 2176. Retrieved 2021/03/26.