(2S,4R)-1-benzyl-4-[(tert-butyldiphenylsilyl)oxy]-2-methoxycarbonylpyrrolidine

Base Information

Chemical Name:(2S,4R)-1-benzyl-4-[(tert-butyldiphenylsilyl)oxy]-2-methoxycarbonylpyrrolidine
CAS No.:882990-52-5
Molecular Formula:C₂₉H₃₅NO₃Si
Molecular Weight:473.687
Hs Code.:

Synonyms:(2S,4R)-1-benzyl-4-[(tert-butyldiphenylsilyl)oxy]-2-methoxycarbonylpyrrolidine

Suppliers and Price of (2S,4R)-1-benzyl-4-[(tert-butyldiphenylsilyl)oxy]-2-methoxycarbonylpyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4R)-1-benzyl-4-[(tert-butyldiphenylsilyl)oxy]-2-methoxycarbonylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R)-1-benzyl-4-[(tert-butyldiphenylsilyl)oxy]-2-methoxycarbonylpyrrolidine

There total 4 articles about (2S,4R)-1-benzyl-4-[(tert-butyldiphenylsilyl)oxy]-2-methoxycarbonylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 882990-52-5
(2S,4R)-1-benzyl-4-[(tert-butyldiphenylsilyl)oxy]-2-methoxycarbonylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / toluene / 6 h / Reflux

2: 1H-imidazole; dmap / N,N-dimethyl-formamide / 6 h / 20 °C

With 1H-imidazole; dmap; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.orglett.0c01252

Reference yield:

: 1499-56-5,775275-31-5,790644-51-8,754962-86-2
(R)-4-hydroxy-L-proline ethyl ester

: 882990-52-5
(2S,4R)-1-benzyl-4-[(tert-butyldiphenylsilyl)oxy]-2-methoxycarbonylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 5 h / Heating

2: DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; triethylamine; In dichloromethane;
DOI:10.1016/j.tet.2005.11.070

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 882990-52-5
(2S,4R)-1-benzyl-4-[(tert-butyldiphenylsilyl)oxy]-2-methoxycarbonylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / 72 h / 20 °C

2: Et₃N / CH₂Cl₂ / 5 h / Heating

3: DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1016/j.tet.2005.11.070