N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

Base Information

• Chemical Name: N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide
• CAS No.: 1189810-89-6
• Molecular Formula: C₂₀H₁₆ClNO₂S
• Molecular Weight: 369.872
• Mol file: 1189810-89-6.mol

Synonyms:N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

Chemical Property of N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

There total 9 articles about N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carbonyl chloride (1189815-88-0) + N-methyl-2-chloroaniline (932-32-1) → N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide (1189810-89-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm2007084

Reference yield:

C14H12O3S (126522-03-0) → N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide (1189810-89-6)

Guidance literature:

Multi-step reaction with 3 steps

1: water; lithium hydroxide / tetrahydrofuran

2: thionyl chloride

3: N-ethyl-N,N-diisopropylamine / dichloromethane

With thionyl chloride; water; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2011.04.124

Reference yield:

4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxylic acid (40808-55-7) → N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide (1189810-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: N-ethyl-N,N-diisopropylamine / dichloromethane

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2011.04.124

upstream raw materials:

3,4-dihydro-1-benzoxepin-5(2H)-one

C₁₄H₁₂O₃S

4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxylic acid

4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carbonyl chloride

Downstream raw materials:

N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carbothioamide